LDLR Activators
Common LDLR Activators include, but are not limited to Atorvastatin CAS 134523-00-5, Ezetimibe CAS 163222-33-1, Fenofibrate CAS 49562-28-9, Berberine hydrochloride CAS 633-65-8 and L-Thyroxine, free acid CAS 51-48-9.
Low-Density Lipoprotein Receptor (LDLR) activators are compounds or molecules that play a vital role in regulating cholesterol homeostasis within the body by promoting the activity of LDL receptors. The LDL receptor is a cell surface protein found primarily in the liver and other tissues. Its main function is to bind to circulating low-density lipoprotein (LDL) particles, often referred to as "bad cholesterol," and facilitate their uptake into cells. This process helps regulate the levels of LDL cholesterol in the bloodstream, preventing its accumulation and reducing the risk of atherosclerosis and cardiovascular diseases.
LDLR activators can modulate the expression and function of LDL receptors, ultimately leading to increased uptake of LDL particles by cells. This activation of LDL receptors promotes the clearance of LDL cholesterol from the bloodstream, lowering its concentration and preventing the development of conditions associated with high cholesterol levels. Research efforts focus on understanding and developing LDLR activators as a means of managing cholesterol metabolism and reducing the risk of heart disease. These activators are an essential component of the complex network that regulates cholesterol balance in the body, highlighting their importance in maintaining overall health and well-being.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis. By reducing intracellular cholesterol, they stimulate the upregulation of LDLR to increase LDL uptake from circulation. | ||||||
Ezetimibe | 163222-33-1 | sc-205690 sc-205690A | 25 mg 100 mg | $96.00 $241.00 | 12 | |
Ezetimibe inhibits intestinal cholesterol absorption, leading to a compensatory increase in LDLR expression in the liver to uptake more LDL from the blood. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fibrates activate PPARα, influencing genes related to lipid metabolism. They can enhance LDLR expression, leading to increased LDL clearance. | ||||||
L-Thyroxine, free acid | 51-48-9 | sc-207813 sc-207813A | 100 mg 500 mg | $35.00 $74.00 | 2 | |
Thyroid hormone can increase LDLR expression, leading to enhanced LDL uptake and reduced plasma LDL levels. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
By binding to its nuclear receptors, retinoic acid can influence the expression of various genes, potentially including LDLR, affecting cholesterol metabolism. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can upregulate LDLR expression, potentially via modulation of liver X receptor (LXR) and SREBP pathways, leading to increased LDL uptake. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein has been shown to upregulate LDLR expression, potentially through its estrogenic effects and modulation of LXR and SREBP pathways. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can stimulate LDLR expression, especially in the liver, leading to increased LDL uptake and reduced circulating LDL levels. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
Omega-3 fatty acids like EPA can upregulate LDLR expression, enhancing LDL uptake and reducing LDL levels in the bloodstream. | ||||||
Guggulsterone | 95975-55-6 | sc-203990 sc-203990A | 10 mg 50 mg | $145.00 $615.00 | 1 | |
Guggulsterone can upregulate LDLR expression, potentially through its action on bile acid receptors and modulation of the LXR pathway. | ||||||