Laminin γ-2 Antibody (H-8): sc-393502

Laminin γ-2 Antibody (H-8) is a mouse monoclonal IgM antibody that detects Laminin γ-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Laminin γ-2 is a crucial component of basement membranes, which are specialized extracellular matrices that provide structural support and influence various cellular functions, including proliferation, migration, and differentiation. Laminin γ-2 forms a heterotrimer composed of α, β, and γ chain subunits, which are secreted by cells and incorporated into the extracellular matrix. This assembly is vital for forming stable basement membranes that surround epithelial layers, blood vessels, and other tissues. The unique structure of Laminin γ-2 enables interactions with various cell surface receptors, such as integrins and dystroglycan, facilitating essential cell-matrix interactions that are critical for tissue integrity and function. The human Laminin γ-2 gene is located on chromosome 1q25-q31 and is specifically expressed in epithelial cells of the skin, lung, and kidney, highlighting its importance in maintaining the architecture and functionality of these tissues. Anti-Laminin γ-2 antibody (H-8) is an invaluable tool for researchers studying this protein′s role in health and disease, particularly in tissue development and repair.

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Laminin γ-2 Antibody (H-8) References:

1. Overexpression of laminin gamma2 chain monomer in invading gastric carcinoma cells.  |  Koshikawa, N., et al. 1999. Cancer Res. 59: 5596-601. PMID: 10554040
2. Involvement of activator protein 1 complexes in the epithelium-specific activation of the laminin gamma2-chain gene promoter by hepatocyte growth factor (scatter factor).  |  Olsen, J., et al. 2000. Biochem J. 347: 407-17. PMID: 10749670
3. Cytoplasmic expression of laminin gamma2 chain correlates with postoperative hepatic metastasis and poor prognosis in patients with pancreatic ductal adenocarcinoma.  |  Takahashi, S., et al. 2002. Cancer. 94: 1894-901. PMID: 11920553
4. Laminin gamma2-chain fragment circulating level increases in patients with metastatic pancreatic ductal cell adenocarcinomas.  |  Katayama, M., et al. 2005. Cancer Lett. 225: 167-76. PMID: 15922869
5. Nerve invasion distance is dependent on laminin gamma2 in tumors of pancreatic cancer.  |  Mitsunaga, S., et al. 2010. Int J Cancer. 127: 805-19. PMID: 20013810
6. MAPK/ERK-dependent translation factor hyperactivation and dysregulated laminin γ2 expression in oral dysplasia and squamous cell carcinoma.  |  Degen, M., et al. 2012. Am J Pathol. 180: 2462-78. PMID: 22546478
7. RSK activation of translation factor eIF4B drives abnormal increases of laminin γ2 and MYC protein during neoplastic progression to squamous cell carcinoma.  |  Degen, M., et al. 2013. PLoS One. 8: e78979. PMID: 24205356
8. Amino-terminal fragments of laminin γ2 chain stimulate migration of metastatic breast cancer cells by interacting with CD44.  |  Sato, H., et al. 2015. Clin Exp Metastasis. 32: 405-15. PMID: 25990436
9. Highly sensitive detection of invasive lung cancer cells by novel antibody against amino-terminal domain of laminin γ2 chain.  |  Miyazaki, K., et al. 2016. Cancer Sci. 107: 1909-1918. PMID: 27685891
10. Development of a fully automated chemiluminescence immunoassay for urine monomeric laminin-γ2 as a promising diagnostic tool of non-muscle invasive bladder cancer.  |  Nakagawa, M., et al. 2017. Biomark Res. 5: 29. PMID: 29046806

The preferred Laminin γ-2 antibody is Laminin γ-2 Antibody (E-6): sc-28330.