Laminin γ-2 Antibody (G-7): sc-393225

Laminin γ-2 Antibody (G-7) is a mouse monoclonal IgG2a antibody that detects Laminin γ-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Laminin γ-2 plays a crucial role in the formation and maintenance of basement membranes, which are vital for tissue integrity and cellular functions. These specialized extracellular matrices provide structural support to various tissues, influencing cell proliferation, migration, and differentiation. Laminin γ-2 is a heterotrimer composed of α, β, and γ chain subunits, which allows for self-assembly and interaction with other matrix components, such as Type IV collagen and proteoglycans. This interaction is essential for the stability and functionality of the basement membrane, as Laminin γ-2 facilitates the binding of cells through receptors like integrins and dystroglycan. Laminin γ-2 is specifically localized to epithelial cells in critical organs such as the skin, lung, and kidney, highlighting its importance in maintaining the architecture and function of these tissues. The human Laminin γ-2 gene is located on chromosome 1q25-q31, and expression is tightly regulated, making Laminin γ-2 a significant marker for various physiological and pathological processes. Anti-Laminin γ-2 antibody (G-7) is an invaluable tool for researchers studying the dynamics of basement membranes and their role in health and disease.

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Laminin γ-2 Antibody (G-7) References:

1. Expression of the laminin gamma2 chain in different histological types of lung carcinoma. A study by immunohistochemistry and in situ hybridization.  |  Määttä, M., et al. 1999. J Pathol. 188: 361-8. PMID: 10440745
2. The short arm of the laminin gamma2 chain plays a pivotal role in the incorporation of laminin 5 into the extracellular matrix and in cell adhesion.  |  Gagnoux-Palacios, L., et al. 2001. J Cell Biol. 153: 835-50. PMID: 11352943
3. Lung development in laminin gamma2 deficiency: abnormal tracheal hemidesmosomes with normal branching morphogenesis and epithelial differentiation.  |  Nguyen, NM., et al. 2006. Respir Res. 7: 28. PMID: 16483354
4. Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury.  |  Katayama, M., et al. 2010. Intensive Care Med. 36: 479-86. PMID: 19940975
5. Expression of laminin gamma2 chain monomer enhances invasive growth of human carcinoma cells in vivo.  |  Tsubota, Y., et al. 2010. Int J Cancer. 127: 2031-41. PMID: 20143393
6. Uncoupled responses of Smad4-deficient cancer cells to TNFalpha result in secretion of monomeric laminin-gamma2.  |  Zboralski, D., et al. 2010. Mol Cancer. 9: 65. PMID: 20307265
7. Regulation of Laminin γ2 Expression by CDX2 in Colonic Epithelial Cells Is Impaired During Active Inflammation.  |  Coskun, M., et al. 2017. J Cell Biochem. 118: 298-307. PMID: 27333824
8. Prognostic significance of circulating laminin gamma2 for early-stage non-small-cell lung cancer.  |  Teng, Y., et al. 2016. Onco Targets Ther. 9: 4151-62. PMID: 27462170
9. Alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer by activating interaction between laminin-γ2 and integrin-β1.  |  Nong, FF., et al. 2022. World J Gastroenterol. 28: 5154-5174. PMID: 36188720
10. Laminin gamma2 expression is developmentally regulated during murine tooth morphogenesis and is intense in ameloblasts.  |  Sahlberg, C., et al. 1998. J Dent Res. 77: 1589-96. PMID: 9719032

The preferred Laminin γ-2 antibody is Laminin γ-2 Antibody (E-6): sc-28330.