Laminin β-2 Antibody (H-1): sc-133241
- Laminin β-2 Antibody (H-1) is a mouse monoclonal IgG2b κ, cited in 8 publications, provided at 200 µg/ml
- raised against amino acids 1549-1798 mapping at the C-terminus of Laminin β-2 of human origin
- recommended for detection of Laminin β-2 of human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for Laminin β-2 Antibody (H-1) for WB applications. This reagent is now offered in a bundle with Laminin β-2 Antibody (H-1) (see ordering information below).
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Laminin β-2 Antibody (H-1) is a mouse monoclonal IgG2b antibody that detects Laminin β-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Laminin β-2 is a critical component of the extracellular matrix, particularly within the basal lamina, where Laminin β-2 plays a vital role in maintaining tissue architecture and integrity. Laminin β-2 is essential for cell adhesion, migration, and differentiation, which are crucial processes during embryonic development and tissue repair. Notably, Laminin β-2 interacts with various integrins and other extracellular matrix proteins, facilitating cellular signaling pathways that influence cell behavior. Laminin β-2′s involvement in melanoma spread highlights its significance in cancer biology, as Laminin β-2 promotes tumor cell migration along the abluminal surface of blood vessels, a process known as extra-vascular migratory metastasis. Anti-Laminin β-2 antibody (H-1) is an invaluable tool for researchers studying the dynamics of cell-matrix interactions and the role of Laminin β-2 in both normal physiology and pathological conditions.
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Laminin β-2 Antibody (H-1) References:
- Expression of laminin beta2: a novel marker of hypoxia in pituitary adenomas. | Bao, Y., et al. 2006. Endocr Pathol. 17: 251-61. PMID: 17308362
- Analysis of genes encoding laminin beta2 and related proteins in patients with Galloway-Mowat syndrome. | Dietrich, A., et al. 2008. Pediatr Nephrol. 23: 1779-86. PMID: 18594871
- Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones. | Chen, J., et al. 2011. J Neurosci. 31: 512-25. PMID: 21228161
- RNA-binding protein IGF2BP2/IMP2 is required for laminin-β2 mRNA translation and is modulated by glucose concentration. | Schaeffer, V., et al. 2012. Am J Physiol Renal Physiol. 303: F75-82. PMID: 22513850
- A novel mutation of laminin β2 (LAMB2) in two siblings with renal failure. | Falix, FA., et al. 2017. Eur J Pediatr. 176: 515-519. PMID: 28188379
- Pathogenicity of a Human Laminin β2 Mutation Revealed in Models of Alport Syndrome. | Funk, SD., et al. 2018. J Am Soc Nephrol. 29: 949-960. PMID: 29263159
- Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions-Brief Report. | Wagner, JUG., et al. 2018. Arterioscler Thromb Vasc Biol. 38: 1170-1177. PMID: 29599141
- Laminin β2 Chain Regulates Retinal Progenitor Cell Mitotic Spindle Orientation via Dystroglycan. | Serjanov, D., et al. 2018. J Neurosci. 38: 5996-6010. PMID: 29853630
- A deletion in the N-terminal polymerizing domain of laminin β2 is a new mouse model of chronic nephrotic syndrome. | Funk, SD., et al. 2020. Kidney Int. 98: 133-146. PMID: 32456966
- Laminin β2 variants associated with isolated nephropathy that impact matrix regulation. | Kikkawa, Y., et al. 2021. JCI Insight. 6: PMID: 33749661
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Laminin β-2 Antibody (H-1) | sc-133241 | 200 µg/ml | $316.00 | |||
Laminin β-2 Antibody (H-1): m-IgG2b BP-HRP Bundle | sc-548489 | 200 µg Ab; 10 µg BP | $354.00 |