Lamin B1 Antibody (E-12): sc-377001
- Lamin B1 Antibody (E-12) is a mouse monoclonal IgG2b κ, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 401-490 mapping near the C-terminus of Lamin B1 of human origin
- recommended for detection of Lamin B1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- See Lamin B1 (A-11): sc-377000 for Lamin B1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Lamin B1 Antibody (E-12) for WB and IHC(P) applications. These reagents are now offered in bundles with Lamin B1 Antibody (E-12) (see ordering information below).
Lamin B1 Antibody (E-12) is a mouse monoclonal IgG2b antibody that detects Lamin B1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Lamin B1 is a crucial component of the nuclear lamina, a fibrous network that provides structural support to the nuclear envelope and plays a vital role in maintaining cellular morphology. This 586 amino acid protein is encoded by a gene that, when mutated, is implicated in the development of autosomal dominant adult-onset leukodystrophy (ADLD), a disorder characterized by cerebellar dysfunction and demyelination of the central nervous system. Notably, Lamin B1 undergoes significant post-translational modifications, including farnesylation and phosphorylation, which are essential for proper localization and function within the nucleus. These modifications not only influence stability and interactions with other nuclear components but also play a role in regulating cell cycle and apoptosis, highlighting Lamin B1′s importance in cellular health and disease. Anti-Lamin B1 antibody (E-12) is an invaluable tool for researchers studying nuclear structure dynamics and Lamin B1′s implications in various pathologies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lamin B1 Antibody (E-12) | sc-377001 | 200 µg/ml | $322.00 | |||
Lamin B1 Antibody (E-12): m-IgG Fc BP-HRP Bundle | sc-538015 | 200 µg Ab; 10 µg BP | $361.00 | |||
Lamin B1 Antibody (E-12): m-IgGκ BP-HRP Bundle | sc-535534 | 200 µg Ab; 40 µg BP | $361.00 | |||
Lamin B1 Antibody (E-12): m-IgG2b BP-HRP Bundle | sc-549914 | 200 µg Ab; 10 µg BP | $361.00 |