Lamin A/C Antibody (636): sc-7292

Lamin A/C Antibody (636) is a mouse monoclonal IgG2b kappa light chain antibody that detects Lamin A and Lamin C proteins of mouse, rat, and human origin through western blotting, immunoprecipitation, immunofluorescence, immunohistochemistry, and flow cytometry. Lamin A/C (636) monoclonal antibody is offered in both conjugated and non-conjugated forms, providing versatility for various experimental needs. Lamin A and C proteins play crucial roles in maintaining structural integrity of the nuclear envelope, which is essential for proper cellular function and morphology. Lamin A and C proteins are located within the nuclear lamina, a dense fibrillar network that underlies the inner nuclear membrane, providing mechanical support and regulating important cellular processes such as DNA replication and cell division. The significance of Lamin A and C extends to involvement in regulation of gene expression and organization of chromatin, which are vital for cellular longevity and stability. Notably, Lamin A is subject to cleavage by specific proteases during apoptosis, highlighting a role in programmed cell death and cellular turnover. Unique structural characteristics of Lamin A and C, including splice variants and post-translational modifications, further underscore importance in cellular dynamics and disease states.

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Lamin A/C Antibody (636) References:

1. Crucial Role of Lamin A/C in the Migration and Differentiation of MSCs in Bone.  |  Alcorta-Sevillano, N., et al. 2020. Cells. 9: PMID: 32466483
2. Lamin A/C and the Immune System: One Intermediate Filament, Many Faces.  |  Saez, A., et al. 2020. Int J Mol Sci. 21: PMID: 32854281
3. Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins.  |  McKeon, FD., et al. Nature. 319: 463-8. PMID: 3453101
4. cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.  |  Fisher, DZ., et al. 1986. Proc Natl Acad Sci U S A. 83: 6450-4. PMID: 3462705
5. TEAD1 trapping by the Q353R-Lamin A/C causes dilated cardiomyopathy.  |  Yamada, S., et al. 2023. Sci Adv. 9: eade7047. PMID: 37058558
6. DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C.  |  Kovacs, MT., et al. 2023. Mol Cell. 83: 3659-3668.e10. PMID: 37832547
7. The dynamic properties and possible functions of nuclear lamins.  |  Moir, RD., et al. 1995. Int Rev Cytol. 162B: 141-82. PMID: 8557486
8. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.  |  Duan, H., et al. 1996. J Biol Chem. 271: 1621-5. PMID: 8576161
9. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.  |  Duan, H., et al. 1996. J Biol Chem. 271: 16720-4. PMID: 8663294
10. Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.  |  Takahashi, A., et al. 1996. Proc Natl Acad Sci U S A. 93: 8395-400. PMID: 8710882
11. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.  |  Fernandes-Alnemri, T., et al. 1996. Proc Natl Acad Sci U S A. 93: 7464-9. PMID: 8755496
12. Lamin proteolysis facilitates nuclear events during apoptosis.  |  Rao, L., et al. 1996. J Cell Biol. 135: 1441-55. PMID: 8978814

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Lamin A/C Antibody (636) has 469 citations in a variety of scientific publications.

Primary antibodies like Anti-Lamin A/C Antibody (636) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Lamin A/C Antibody (636) Specifications

Alternate Product Name: Lamin A/C

Product Clone Name: 636

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: Lamin A/C

Epitope Species: porcine

Product Reactivity/Detection: Lamin A and Lamin C

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 469 citations in various scientific publications

Available Conjugates/Forms for Lamin A/C Antibody (636): AC: Agarose, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, PE: Phycoerythrin, X: TransCruz Reagent