Lamin C Inhibitors
Lamin C inhibitors are a class of chemical compounds that specifically target and interfere with the normal function of lamin C, a crucial component of the nuclear lamina. The nuclear lamina is a dense fibrillar network situated inside the nuclear envelope in eukaryotic cells. It provides structural support to the nucleus and plays a significant role in many nuclear activities, including DNA replication, transcription, and nuclear assembly. Lamin C, along with other lamins, constitutes the main structural proteins of this network. These proteins are type V intermediate filament proteins and are pivotal in maintaining nuclear integrity and shaping, as well as acting as a scaffold for binding chromatin and other nuclear components.
The chemical compounds that fall under the category of lamin C inhibitors function by binding to lamin C or its associated proteins, thus disrupting its normal activity. Given the intricate role of lamin C in nuclear processes, its inhibitors can significantly affect the stability of the nuclear envelope and the various cellular functions associated with the nuclear lamina. The specificity of these inhibitors varies, with some showing high selectivity for lamin C, while others might affect multiple lamin proteins. The exact mechanism of action and binding sites can differ between individual compounds, depending on their chemical structure and the nature of their interaction with the lamin C protein or its associated molecular partners. Consequently, the effects of these inhibitors are diverse, ranging from changes in nuclear morphology to alterations in specific cellular functions linked to the nuclear lamina.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is an oxidized form of Vitamin A. It plays roles in development, vision, and the immune response. Retinoic acid can influence the differentiation of certain cell types, and during this process, there are alterations in gene expression profiles. Lamin A/C expression can be affected by retinoic acid in certain contexts. However, retinoic acid doesn't directly "inhibit" Lamin C; instead, it can modulate its expression in certain cells. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables like broccoli. It's known for its potential anticancer and antioxidant properties. Sulforaphane can induce certain cytoprotective genes and has been shown to affect nuclear architecture in some studies. While it doesn't specifically target Lamin C, changes to nuclear architecture can indirectly involve lamins. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Lovastatin is a member of the statin class of chemicals used primarily to lower blood cholesterol levels. Statins can influence the processing of prelamin A due to their effect on the mevalonate pathway and the subsequent reduction in farnesyl groups available for post-translational modification. This doesn't specifically inhibit Lamin C but can affect lamin dynamics and processing in the cell. | ||||||
Tipifarnib | 192185-72-1 | sc-364637 | 10 mg | $720.00 | ||
Tipifarnib is a Farnesyltransferase inhibitor. FTIs were initially developed as anti-cancer agents. FTIs can prevent the farnesylation of prelamin A. Mutations in lamin A can lead to a form of the protein that remains farnesylated, contributing to diseases like progeria. By inhibiting farnesylation, FTIs can counteract some of the negative effects of these mutations. However, their primary target isn't Lamin C. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A (BPA) is an organic synthetic compound used in the production of certain plastics. BPA has been shown to affect nuclear morphology in some studies. While it doesn't directly target Lamin C, any changes to nuclear morphology and structure can involve lamins as they are primary components of the nuclear lamina. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a known microtubule-depolymerizing agent. While its primary action is on microtubules, nocodazole can indirectly influence nuclear shape and potentially lamins. It's not a direct inhibitor of Lamin C but can influence cellular structures that interact with lamins. | ||||||