LAIR-1 Antibody (G-1): sc-398140

LAIR-1 Antibody (G-1) is a mouse monoclonal IgG2b antibody that detects leukocyte-associated Ig-like receptor-1 (LAIR-1) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LAIR-1 is a transmembrane glycoprotein predominantly expressed on human peripheral blood mononuclear leukocytes, playing a crucial role in immune regulation. LAIR-1 is located on the cell surface, where LAIR-1 functions as an inhibitory receptor that modulates immune responses by recruiting SHP-1, a phosphatase that negatively regulates cell signaling pathways. This interaction is vital for maintaining the balance of immune activation and inhibition, particularly in T lymphocytes, where LAIR-1 helps establish signaling thresholds essential for T cell receptor (TCR) signaling. The phosphorylation of LAIR-1 at specific tyrosine residues, such as Tyr 233 and Tyr 263, is critical for LAIR-1 function, as phosphorylation facilitates SHP-1 recruitment and influences downstream signaling events. Notably, LAIR-1 engagement on myelomonocytic leukemic cell lines has been shown to inhibit cell proliferation and induce programmed cell death, while cross-linking LAIR-1 on natural killer (NK) cells significantly dampens their cytotoxic activity. Understanding LAIR-1′s role in immune regulation is important for developing therapeutic strategies targeting immune responses in various diseases.

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LAIR-1 Antibody (G-1) References:

1. The role of LAIR-1 (CD305) in T cells and monocytes/macrophages in patients with rheumatoid arthritis.  |  Zhang, Y., et al. 2014. Cell Immunol. 287: 46-52. PMID: 24380839
2. A non-stimulatory monoclonal antibody against the inhibitory immunoreceptor LAIR-1.  |  Xie, X., et al. 2014. Monoclon Antib Immunodiagn Immunother. 33: 141-7. PMID: 24694245
3. C1q-mediated repression of human monocytes is regulated by leukocyte-associated Ig-like receptor 1 (LAIR-1).  |  Son, M. and Diamond, B. 2015. Mol Med. 20: 559-68. PMID: 25247291
4. LAIR-1 shedding from human fibroblast-like synoviocytes in rheumatoid arthritis following TNF-α stimulation.  |  Zhang, Y., et al. 2018. Clin Exp Immunol. 192: 193-205. PMID: 29328500
5. Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.  |  Xu, K., et al. 2021. Nat Commun. 12: 4226. PMID: 34244481
6. Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1.  |  Keerthivasan, S., et al. 2021. Immunity. 54: 1511-1526.e8. PMID: 34260887
7. Cytotoxic T Cell Expression of Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) in Viral Hepatitis C-Mediated Hepatocellular Carcinoma.  |  Hammad, R., et al. 2022. Int J Mol Sci. 23: PMID: 36293412
8. LAIR1-mediated resistance of hepatocellular carcinoma cells to T cells through a GSK-3β/β-catenin/MYC/PD-L1 pathway.  |  Pan, B., et al. 2024. Cell Signal. 115: 111039. PMID: 38199599
9. Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is reduced with preeclampsia and small for gestational aged fetuses.  |  Bartho, LA., et al. 2024. Placenta. 156: 10-13. PMID: 39216164
10. Mechanistic role of FN1 in LAIR-1 mediated downregulation of ovarian cancer cell proliferation.  |  Zhang, H., et al. 2025. BMC Cancer. 25: 339. PMID: 40000955

The preferred LAIR-1 antibody is LAIR-1 Antibody (F-5): sc-398141.