L3MBTL2 Antibody (F-3): sc-365134
- L3MBTL2 Antibody (F-3) is a mouse monoclonal IgG2b κ L3MBTL2 antibody provided at 200 µg/ml
- raised against amino acids 141-193 mapping within an internal region of L3MBTL2 of human origin
- L3MBTL2 Antibody (F-3) is recommended for detection of L3MBTL2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-L3MBTL2 Antibody (F-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for L3MBTL2 Antibody (F-3) for WB applications. These reagents are now offered in bundles with L3MBTL2 Antibody (F-3) (see ordering information below).
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L3MBTL2 Antibody (F-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects L3MBTL2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-L3MBTL2 antibody (F-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. L3MBTL2, also known as Lethal(3)malignant brain tumor-like 2 protein, is a crucial member of the Polycomb group (PcG) proteins, which play a significant role in maintaining the transcriptionally repressed state of target genes through chromatin modification. L3MBTL2 is localized in the nucleus, where L3MBTL2 associates with chromatin-remodeling complexes to inhibit the expression of proteins that promote cell cycle progression into mitosis. During the G0 phase of the cell cycle, L3MBTL2 forms a complex with other proteins, such as HP1γ, E2F-6, and Max, which are essential for transcriptional repression. Structurally, L3MBTL2 consists of 705 amino acids and features one FCS-type zinc finger and four MBT repeats, with L3MBTL2 expression resulting in three isoforms due to alternative splicing. L3MBTL2′s ability to regulate gene expression is vital for cellular differentiation and development, making L3MBTL2 an important target for research in cancer and developmental biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
L3MBTL2 Antibody (F-3) References:
- The DNA sequence of human chromosome 22. | Dunham, I., et al. 1999. Nature. 402: 489-95. PMID: 10591208
- Molecular characterization of h-l(3)mbt-like: a new member of the human mbt family. | Wismar, J. 2001. FEBS Lett. 507: 119-21. PMID: 11682070
- A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. | Ogawa, H., et al. 2002. Science. 296: 1132-6. PMID: 12004135
- Proliferation-linked expression of the novel murine gene m4mbt encoding a nuclear zinc finger protein with four mbt domains. | Markus, J., et al. 2003. Gene. 319: 117-26. PMID: 14597177
- Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies. | Li, J., et al. 2004. Proc Natl Acad Sci U S A. 101: 7341-6. PMID: 15123827
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L3MBTL2 Antibody (F-3) | sc-365134 | 200 µg/ml | $322.00 | |||
L3MBTL2 Antibody (F-3): m-IgG Fc BP-HRP Bundle | sc-525859 | 200 µg Ab; 10 µg BP | $361.00 | |||
L3MBTL2 Antibody (F-3): m-IgG2b BP-HRP Bundle | sc-549639 | 200 µg Ab; 10 µg BP | $361.00 | |||
L3MBTL2 Antibody (F-3) AC | sc-365134 AC | 500 µg/ml, 25% agarose | $424.00 | |||
L3MBTL2 Antibody (F-3) HRP | sc-365134 HRP | 200 µg/ml | $322.00 | |||
L3MBTL2 Antibody (F-3) FITC | sc-365134 FITC | 200 µg/ml | $336.00 | |||
L3MBTL2 Antibody (F-3) PE | sc-365134 PE | 200 µg/ml | $349.00 | |||
L3MBTL2 Antibody (F-3) Alexa Fluor® 488 | sc-365134 AF488 | 200 µg/ml | $364.00 | |||
L3MBTL2 Antibody (F-3) Alexa Fluor® 546 | sc-365134 AF546 | 200 µg/ml | $364.00 | |||
L3MBTL2 Antibody (F-3) Alexa Fluor® 594 | sc-365134 AF594 | 200 µg/ml | $364.00 | |||
L3MBTL2 Antibody (F-3) Alexa Fluor® 647 | sc-365134 AF647 | 200 µg/ml | $364.00 | |||
L3MBTL2 Antibody (F-3) Alexa Fluor® 680 | sc-365134 AF680 | 200 µg/ml | $364.00 | |||
L3MBTL2 Antibody (F-3) Alexa Fluor® 790 | sc-365134 AF790 | 200 µg/ml | $364.00 |