L-Selectin/CD62L/SELL Antibody (3H1611): sc-71476

L-Selectin Antibody (3H1611) is a mouse monoclonal IgG2b antibody that detects L-Selectin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). L-Selectin, also known as LECAM-1 or CD62L, plays a crucial role in the immune response by mediating the adhesion of leukocytes to the endothelium, which is essential for the migration of immune cells to sites of inflammation. L-Selectin is predominantly expressed on the surface of naive T cells, B cells, and various types of leukocytes, including monocytes, neutrophils, and eosinophils. L-Selectin′s ability to interact with specific carbohydrates on activated endothelial cells facilitates the initial steps of leukocyte extravasation, a process vital for effective immune surveillance and response. The structural features of L-Selectin, including its lectin-like domain, are important for binding affinity and specificity to ligands such as sialyl-Lex, which are expressed on activated endothelial cells. Anti-L-Selectin antibody (3H1611) enables researchers to gain insights into the mechanisms of immune cell trafficking and L-Selectin′s role in various pathological conditions, including inflammatory diseases and cancer.

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L-Selectin/CD62L/SELL Antibody (3H1611) References:

1. Elevated serum L-selectin levels and decreased L-selectin expression on CD8(+) lymphocytes in systemic sclerosis.  |  Shimada, Y., et al. 2001. Clin Exp Immunol. 124: 474-9. PMID: 11472411
2. Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan.  |  Sarangapani, KK., et al. 2004. J Biol Chem. 279: 2291-8. PMID: 14573602
3. L-Selectin ligands in lymphoid tissues and models of inflammation.  |  Khan, AI., et al. 2003. Inflammation. 27: 265-80. PMID: 14635784
4. An integrated view of L-selectin and trophinin function in human embryo implantation.  |  Fukuda, MN. and Sugihara, K. 2008. J Obstet Gynaecol Res. 34: 129-36. PMID: 18412772
5. Role of c-Abl in L-selectin shedding from the neutrophil surface.  |  Ball, CJ. and King, MR. 2011. Blood Cells Mol Dis. 46: 246-51. PMID: 21277237
6. The association of L-selectin polymorphisms with L-selectin serum levels and risk of ischemic stroke.  |  Wei, YS., et al. 2011. J Thromb Thrombolysis. 32: 110-5. PMID: 21465128
7. Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues.  |  Carlson, GE., et al. 2017. PLoS One. 12: e0173747. PMID: 28282455
8. Plasma soluble L-selectin in medicated patients with schizophrenia and healthy controls.  |  Mohite, S., et al. 2017. PLoS One. 12: e0174073. PMID: 28334045
9. PI3K Is a Linker Between L-selectin and PSGL-1 Signaling to IL-18 Transcriptional Activation at the Promoter Level.  |  Luo, J. 2018. Inflammation. 41: 555-561. PMID: 29218606
10. Increased L-Selectin on Monocytes Is Linked to the Autoantibody Profile in Systemic Sclerosis.  |  Brezovec, N., et al. 2022. Int J Mol Sci. 23: PMID: 35216350

The preferred L-Selectin/CD62L/SELL antibody is L-Selectin/CD62L/SELL Antibody (lam1-116): sc-13505.