L-Plastin Antibody (C-4): sc-133219
- L-Plastin Antibody (C-4) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 298-331 within an internal region of L-Plastin of human origin
- recommended for detection of L-Plastin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for L-Plastin Antibody (C-4) for WB and IHC(P) applications. These reagents are now offered in bundles with L-Plastin Antibody (C-4) (see ordering information below).
L-Plastin Antibody (C-4) is a mouse monoclonal IgG1 antibody that detects L-Plastin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). L-Plastin, a member of the plastin family of actin-binding proteins, plays a crucial role in cytoskeletal organization and is particularly important in regulating cell adhesion and motility, especially in hematopoietic cells. L-Plastin expression is notably elevated in various human cancer cell lines derived from solid tumors, highlighting L-Plastin involvement in cancer invasion and metastasis. L-Plastin ability to modulate leukocyte adhesion is critical for immune responses, and L-Plastin phosphorylation status is essential for the regulation of integrin signaling pathways, which are vital for cell communication and movement. Anti-L-Plastin antibody (C-4) is an invaluable tool for researchers studying the dynamics of cell behavior in both normal and pathological conditions, providing insights into the mechanisms underlying cancer progression and immune function.
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L-Plastin Antibody (C-4) References:
- L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes. | Freeley, M., et al. 2012. J Immunol. 188: 6357-70. PMID: 22581862
- The actin-bundling protein L-plastin: a novel local inflammatory marker associated with periodontitis. | Öztürk, VÖ., et al. 2015. J Periodontal Res. 50: 337-46. PMID: 25040533
- L-plastin Ser5 phosphorylation in breast cancer cells and in vitro is mediated by RSK downstream of the ERK/MAPK pathway. | Lommel, MJ., et al. 2016. FASEB J. 30: 1218-33. PMID: 26631483
- L-Plastin promotes podosome longevity and supports macrophage motility. | Zhou, JY., et al. 2016. Mol Immunol. 78: 79-88. PMID: 27614263
- Exosomal Release of L-Plastin by Breast Cancer Cells Facilitates Metastatic Bone Osteolysis. | Tiedemann, K., et al. 2019. Transl Oncol. 12: 462-474. PMID: 30583289
- Reduced exosomal L-Plastin is responsible for radiation-induced bystander effect. | Freudenmann, LK., et al. 2019. Exp Cell Res. 383: 111498. PMID: 31302031
- L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction. | Chellaiah, MA., et al. 2020. Bone Res. 8: 3. PMID: 31993243
- The actin-bundling protein L-plastin-A double-edged sword: Beneficial for the immune response, maleficent in cancer. | Schaffner-Reckinger, E. and Machado, RAC. 2020. Int Rev Cell Mol Biol. 355: 109-154. PMID: 32859369
- Targeting actin-bundling protein L-plastin as an anabolic therapy for bone loss. | Li, X., et al. 2020. Sci Adv. 6: PMID: 33208358
- L-plastin associated syndrome of immune deficiency and hematologic cytopenia. | Hernandez, RA., et al. 2024. J Allergy Clin Immunol. 154: 767-777. PMID: 38710235
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Plastin Antibody (C-4) | sc-133219 | 200 µg/ml | $322.00 | |||
L-Plastin Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-537358 | 200 µg Ab; 10 µg BP | $361.00 | |||
L-Plastin Antibody (C-4): m-IgGκ BP-HRP Bundle | sc-534603 | 200 µg Ab; 40 µg BP | $361.00 | |||
L-Plastin Antibody (C-4): m-IgG1 BP-HRP Bundle | sc-545155 | 200 µg Ab; 20 µg BP | $361.00 | |||
L-Plastin (C-4) Neutralizing Peptide | sc-133219 P | 100 µg/0.5 ml | $69.00 |