KVβ.2 Antibody (A-3): sc-393014
- KVβ.2 Antibody (A-3) is a mouse monoclonal IgG2a κ KVβ.2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 28-52 near the N-terminus of KVβ.2 of human origin
- recommended for detection of KVβ.2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KVβ.2 Antibody (A-3) for WB applications. These reagents are now offered in bundles with KVβ.2 Antibody (A-3) (see ordering information below).
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KVβ.2 Antibody (A-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects KVβ.2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KVβ.2 antibody (A-3) is available as non-conjugated. KVβ.2 protein, also known as KCNAB2, plays a crucial role as an auxiliary subunit of voltage-gated potassium channels, which are essential for regulating neuronal excitability and muscle contraction. By modulating gating properties of pore-forming alpha subunits, KVβ.2 influences kinetics of channel activation and inactivation, thereby affecting repolarization phase of action potentials. This modulation is vital for maintaining proper electrical activity of excitable cells, and dysregulation of KV channels has been implicated in various neurological disorders and cardiac arrhythmias. KV gene family, which includes over 30 genes, encodes these subunits, and specific interactions between KVβ.2 and alpha subunits are critical for assembly and functional expression of these channels. Understanding KVβ.2′s role in channel dynamics not only sheds light on fundamental cellular processes but also opens avenues for therapeutic interventions targeting channelopathies.
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KVβ.2 Antibody (A-3) References:
- Subunit composition of Kv1 channels in human CNS. | Coleman, SK., et al. 1999. J Neurochem. 73: 849-58. PMID: 10428084
- Subunit composition determines Kv1 potassium channel surface expression. | Manganas, LN. and Trimmer, JS. 2000. J Biol Chem. 275: 29685-93. PMID: 10896669
- The brain Kv1.1 potassium channel: in vitro and in vivo studies on subunit assembly and posttranslational processing. | Deal, KK., et al. 1994. J Neurosci. 14: 1666-76. PMID: 8126562
- Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain. | Veh, RW., et al. 1995. Eur J Neurosci. 7: 2189-205. PMID: 8563969
- Beta subunits promote K+ channel surface expression through effects early in biosynthesis. | Shi, G., et al. 1996. Neuron. 16: 843-52. PMID: 8608002
- Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes. | Rhodes, KJ., et al. 1997. J Neurosci. 17: 8246-58. PMID: 9334400
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KVβ.2 Antibody (A-3) | sc-393014 | 200 µg/ml | $322.00 | |||
KVβ.2 Antibody (A-3): m-IgG Fc BP-HRP Bundle | sc-538118 | 200 µg Ab; 10 µg BP | $361.00 | |||
KVβ.2 Antibody (A-3): m-IgGκ BP-HRP Bundle | sc-535673 | 200 µg Ab; 40 µg BP | $361.00 | |||
KVβ.2 (A-3) Neutralizing Peptide | sc-393014 P | 100 µg/0.5 ml | $69.00 |