KVβ Antibody (F-7): sc-377099
- KVβ Antibody (F-7) is a mouse monoclonal IgG1 κ KVβ antibody provided at 200 µg/ml
- raised against amino acids 120-419 mapping at the C-terminus of KVβ.1 of human origin
- KV beta Antibody (F-7) is recommended for detection of KVβ.1 and KVβ.2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-KV beta Antibody (F-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for KVβ Antibody (F-7). This work is in progress.
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KVβ Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects KVβ protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KVβ (F-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KVβ protein, also known as KCNAB1, plays a crucial role as an accessory subunit in voltage-gated potassium channels, which are essential for the proper functioning of excitable cells such as neurons and muscle cells. These channels are responsible for repolarizing the membrane after action potentials, thereby influencing the frequency and timing of neuronal firing. The KV gene family encodes over 30 proteins that form the subunits of these channels, and KVβ specifically modulates the activity of the pore-forming alpha subunits, which are organized as tetramers. KVβ is particularly significant in the brain, where KVβ is predominantly expressed in regions such as the caudate nucleus, hippocampus, and thalamus, highlighting its importance in neural signaling and potential implications in neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KVβ Antibody (F-7) References:
- Subunit composition determines Kv1 potassium channel surface expression. | Manganas, LN. and Trimmer, JS. 2000. J Biol Chem. 275: 29685-93. PMID: 10896669
- Characterization of a voltage-gated K+ channel beta subunit expressed in human heart. | England, SK., et al. 1995. Proc Natl Acad Sci U S A. 92: 6309-13. PMID: 7603988
- Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. | McCormack, K., et al. 1995. FEBS Lett. 370: 32-6. PMID: 7649300
- Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium. | Majumder, K., et al. 1995. FEBS Lett. 361: 13-6. PMID: 7890032
- A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits. | Morales, MJ., et al. 1995. J Biol Chem. 270: 6272-7. PMID: 7890764
- A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing. | England, SK., et al. 1995. J Biol Chem. 270: 28531-4. PMID: 7499366
- Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B). | Leicher, T., et al. 1996. Neuropharmacology. 35: 787-95. PMID: 8938711
- Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. | Leicher, T., et al. 1998. J Biol Chem. 273: 35095-101. PMID: 9857044
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KVβ Antibody (F-7) | sc-377099 | 200 µg/ml | $322.00 | |||
KVβ Antibody (F-7) AC | sc-377099 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KVβ Antibody (F-7) HRP | sc-377099 HRP | 200 µg/ml | $322.00 | |||
KVβ Antibody (F-7) FITC | sc-377099 FITC | 200 µg/ml | $336.00 | |||
KVβ Antibody (F-7) PE | sc-377099 PE | 200 µg/ml | $349.00 | |||
KVβ Antibody (F-7) Alexa Fluor® 488 | sc-377099 AF488 | 200 µg/ml | $364.00 | |||
KVβ Antibody (F-7) Alexa Fluor® 546 | sc-377099 AF546 | 200 µg/ml | $364.00 | |||
KVβ Antibody (F-7) Alexa Fluor® 594 | sc-377099 AF594 | 200 µg/ml | $364.00 | |||
KVβ Antibody (F-7) Alexa Fluor® 647 | sc-377099 AF647 | 200 µg/ml | $364.00 | |||
KVβ Antibody (F-7) Alexa Fluor® 680 | sc-377099 AF680 | 200 µg/ml | $364.00 | |||
KVβ Antibody (F-7) Alexa Fluor® 790 | sc-377099 AF790 | 200 µg/ml | $364.00 |