KVβ.1 Antibody (H-5): sc-373986

KVβ.1 Antibody (H-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects KVβ.1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-KVβ.1 antibody (H-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KVβ.1 plays a crucial role as an accessory subunit of voltage-gated potassium channels, which are essential for the regulation of electrical excitability in neurons and muscle cells. These channels are responsible for repolarizing the membrane potential after action potentials, thereby influencing the frequency and timing of neuronal firing and muscle contractions. The KV gene family, which includes over 30 different proteins, encodes the subunits that form these channels, and their diverse gating and permeation properties are vital for proper cellular function. KVβ.1 specifically modulates the activity of the pore-forming α subunits, enhancing the stability and functionality of the potassium channels. Notably, KVβ.1 is predominantly expressed in the brain, particularly in regions such as the caudate nucleus, hippocampus, and thalamus, as well as in the amygdala and subthalamic nucleus. In the cardiovascular system, KVβ.1 is significantly more abundant in the left ventricle compared to the left atrium, highlighting its potential role in cardiac physiology and pathophysiology.

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KVβ.1 Antibody (H-5) References:

1. Subunit composition determines Kv1 potassium channel surface expression.  |  Manganas, LN. and Trimmer, JS. 2000. J Biol Chem. 275: 29685-93. PMID: 10896669
2. Developmental regulation of the A-type potassium-channel current in hippocampal neurons: role of the Kvbeta 1.1 subunit.  |  Falk, T., et al. 2003. Neuroscience. 120: 387-404. PMID: 12890510
3. Structural basis for competition between drug binding and Kvbeta 1.3 accessory subunit-induced N-type inactivation of Kv1.5 channels.  |  Decher, N., et al. 2005. Mol Pharmacol. 68: 995-1005. PMID: 16024663
4. NADPH binding to beta-subunit regulates inactivation of voltage-gated K(+) channels.  |  Tipparaju, SM., et al. 2007. Biochem Biophys Res Commun. 359: 269-76. PMID: 17540341
5. Estrogen regulation of genes important for K+ channel signaling in the arcuate nucleus.  |  Roepke, TA., et al. 2007. Endocrinology. 148: 4937-51. PMID: 17595223
6. A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing.  |  England, SK., et al. 1995. J Biol Chem. 270: 28531-4. PMID: 7499366
7. Characterization of a voltage-gated K+ channel beta subunit expressed in human heart.  |  England, SK., et al. 1995. Proc Natl Acad Sci U S A. 92: 6309-13. PMID: 7603988
8. Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product.  |  McCormack, K., et al. 1995. FEBS Lett. 370: 32-6. PMID: 7649300
9. Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium.  |  Majumder, K., et al. 1995. FEBS Lett. 361: 13-6. PMID: 7890032
10. A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits.  |  Morales, MJ., et al. 1995. J Biol Chem. 270: 6272-7. PMID: 7890764
11. Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B).  |  Leicher, T., et al. 1996. Neuropharmacology. 35: 787-95. PMID: 8938711
12. Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel.  |  Leicher, T., et al. 1998. J Biol Chem. 273: 35095-101. PMID: 9857044

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KVβ.1 Antibody (H-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-KVβ.1 Antibody (H-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KVβ.1 Antibody (H-5) Specifications

Alternate Product Name: KVβ.1

Product Clone Name: H-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 327-351

Epitope Target: KVβ.1

Epitope Species: human

Product Reactivity/Detection: KVβ.1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for KVβ.1 Antibody (H-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred KVβ antibody is KVβ Antibody (F-7): sc-377099.