Ku86 Antibody (Ku15): sc-33653
- Ku86 Antibody (Ku15) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against a 431 human epidermoid carcinoma cell line
- recommended for detection of Ku86 of human origin by WB, IP, IF and IHC(P)
- See Ku86 (B-1): sc-5280 for Ku86 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Ku86 Antibody (Ku15) for WB and IHC(P) applications. These reagents are now offered in bundles with Ku86 Antibody (Ku15) (see ordering information below).
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Ku86 Antibody (Ku15) is a mouse monoclonal IgG1 antibody that detects Ku86 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Ku86, also known as Ku80 or p80, is a critical component of the Ku protein complex, which plays a vital role in DNA repair and maintenance of genomic stability. Ku86 is primarily localized in the nucleus, where anti-Ku86 antibody (Ku15) detects heterodimer formation with Ku70 (p70) to bind to DNA double-strand breaks, facilitating the non-homologous end joining (NHEJ) repair pathway. Ku86′s nuclear localization ensures rapid response to DNA damage, which is crucial for preventing mutations and maintaining cellular integrity. Additionally, Ku86 monoclonal antibody (Ku15) can detect interactions with RNA polymerase II and other transcription factors involved in modulating gene expression. Anti-Ku86 antibody (Ku15) serves as an essential tool for researchers studying DNA repair mechanisms, transcriptional regulation, and the pathophysiology of diseases associated with genomic instability.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ku86 Antibody (Ku15) | sc-33653 | 200 µg/ml | $316.00 | |||
Ku86 Antibody (Ku15): m-IgG Fc BP-HRP Bundle | sc-536769 | 200 µg Ab; 10 µg BP | $354.00 | |||
Ku86 Antibody (Ku15): m-IgGκ BP-HRP Bundle | sc-533933 | 200 µg Ab; 40 µg BP | $354.00 | |||
Ku86 Antibody (Ku15): m-IgG1 BP-HRP Bundle | sc-544810 | 200 µg Ab; 20 µg BP | $354.00 |