KLF3 Antibody (H-8): sc-393041

KLF3 Antibody (H-8) is a mouse monoclonal IgG1 antibody that detects KLF3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KLF3, a member of the Krüppel-like factor family, is a transcription factor that plays a crucial role in regulating gene expression during hematopoiesis, the process of blood cell formation. Anti-KLF3 antibody (H-8) recognizes the protein primarily in the nucleus, where KLF3 binds to specific DNA sequences to modulate the transcription of target genes, thereby influencing cell differentiation and proliferation. KLF3′s nuclear localization enables precise control over gene expression in response to various physiological signals, which is essential for maintaining normal blood cell development and function. KLF3 interacts with other proteins, such as GATA-1 and NF-E2, which are also involved in hematopoiesis, highlighting KLF3′s role in a complex regulatory network that ensures proper blood cell lineage specification. KLF3 monoclonal antibody (H-8) serves as an invaluable tool for researchers studying the mechanisms of blood cell development and the underlying causes of hematological disorders.

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KLF3 Antibody (H-8) References:

1. The mammalian zinc finger transcription factor Krüppel-like factor 3 (KLF3/BKLF).  |  Pearson, RC., et al. 2011. IUBMB Life. 63: 86-93. PMID: 21360637
2. Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis.  |  Liu, Y., et al. 2018. Biochem J. 475: 3629-3638. PMID: 30341166
3. MiR-326/Sp1/KLF3: A novel regulatory axis in lung cancer progression.  |  Wang, R., et al. 2019. Cell Prolif. 52: e12551. PMID: 30485570
4. KLF3 is a crucial regulator of metastasis by controlling STAT3 expression in lung cancer.  |  Sun, W., et al. 2019. Mol Carcinog. 58: 1933-1945. PMID: 31486564
5. LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis.  |  Mao, Q., et al. 2019. Stem Cell Res Ther. 10: 393. PMID: 31847890
6. miR-660-5p-loaded M2 macrophages-derived exosomes augment hepatocellular carcinoma development through regulating KLF3.  |  Tian, B., et al. 2021. Int Immunopharmacol. 101: 108157. PMID: 34673296
7. Long Noncoding RNA KLF3-AS1 Acts as an Endogenous RNA of miR-223 to Attenuate Gastric Cancer Progression and Chemoresistance.  |  Jiang, H., et al. 2021. Front Oncol. 11: 704339. PMID: 34745937
8. Bone marrow mesenchymal stem cell-derived exosomal lncRNA KLF3-AS1 stabilizes Sirt1 protein to improve cerebral ischemia/reperfusion injury via miR-206/USP22 axis.  |  Xie, X., et al. 2023. Mol Med. 29: 3. PMID: 36627572
9. The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells.  |  Chen, S., et al. 2023. Cell Tissue Res. 393: 97-109. PMID: 37052702
10. MSC Promotes the Secretion of Exosomal lncRNA KLF3-AS1 to Regulate Sphk1 Through YY1-Musashi-1 Axis and Improve Cerebral Ischemia-Reperfusion Injury.  |  Cao, Y., et al. 2024. Mol Neurobiol. 61: 10462-10480. PMID: 38735900

The preferred KLF3 antibody is KLF3 Antibody (B-12): sc-514500.