KLF3 Antibody (B-12): sc-514500

KLF3 Antibody (B-12) is a mouse monoclonal IgG3 kappa light chain antibody that detects KLF3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KLF3 antibody (B-12) is available as the non-conjugated form. KLF3, a member of the Krüppel-like factor family, plays a crucial role in regulating gene expression related to cell growth, differentiation, and hematopoiesis. KLF3′s ability to function as either an activator or repressor of transcription is determined by specific promoter binding and coregulator interactions, making KLF3 a vital component in various biological processes. KLF3 has been implicated in regulating hematopoietic stem cell function, influencing blood cell development and maintenance. Understanding KLF3′s interactions with other proteins, such as KLF6, which is involved in tissue injury responses, highlights KLF3′s importance in cellular signaling pathways and potential therapeutic targets in hematological disorders.

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KLF3 Antibody (B-12) References:

1. Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription.  |  van Vliet, J., et al. 2000. Nucleic Acids Res. 28: 1955-62. PMID: 10756197
2. The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2.  |  Turner, J., et al. 2003. J Biol Chem. 278: 12786-95. PMID: 12556451
3. Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs.  |  Yang, XO., et al. 2003. Blood. 101: 4492-9. PMID: 12576331
4. Sp1- and Krüppel-like transcription factors.  |  Kaczynski, J., et al. 2003. Genome Biol. 4: 206. PMID: 12620113
5. Cell and tissue specific expression of human Krüppel-like transcription factors in human ocular surface.  |  Chiambaretta, F., et al. 2004. Mol Vis. 10: 901-9. PMID: 15570219
6. Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation.  |  Ghaleb, AM., et al. 2005. Cell Res. 15: 92-6. PMID: 15740636
7. KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding sites.  |  Himeda, CL., et al. 2010. Mol Cell Biol. 30: 3430-43. PMID: 20404088
8. Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3).  |  Knights, AJ., et al. 2016. J Biol Chem. 291: 16048-58. PMID: 27226561
9. The Exosomal lncRNA KLF3-AS1 From Ischemic Cardiomyocytes Mediates IGF-1 Secretion by MSCs to Rescue Myocardial Ischemia-Reperfusion Injury.  |  Chen, G., et al. 2021. Front Cardiovasc Med. 8: 671610. PMID: 34621793
10. Exosomal lncRNA KLF3-AS1 derived from bone marrow mesenchymal stem cells stimulates angiogenesis to promote diabetic cutaneous wound healing.  |  Han, ZF., et al. 2022. Diabetes Res Clin Pract. 183: 109126. PMID: 34742784
11. Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis.  |  Wen, C., et al. 2022. Cell Cycle. 21: 289-303. PMID: 34964696
12. Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression.  |  Shan, HJ., et al. 2022. Bioengineered. 13: 8038-8050. PMID: 35311620

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KLF3 Antibody (B-12) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-KLF3 Antibody (B-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KLF3 Antibody (B-12) Specifications

Alternate Product Name: KLF3

Product Clone Name: B-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 175-192

Epitope Target: KLF3

Epitope Species: human

Product Reactivity/Detection: KLF3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for KLF3 Antibody (B-12): P: Blocking Peptide, X: TransCruz Reagent