KLC1 Antibody (L2): sc-58776

KLC1 Antibody (L2) is a mouse monoclonal IgG2a kappa light chain antibody that detects KLC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KLC1 antibody (L2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The kinesin light chain 1 (KLC1) protein plays a crucial role in intracellular transport, functioning as a key component of the kinesin motor protein complex, which is essential for the movement of cellular cargo along microtubules. KLC1 is primarily located in the cytoplasm, where KLC1 interacts with kinesin heavy chains to facilitate the transport of organelles, vesicles, and protein complexes, thereby maintaining cellular organization and function. Proper functioning of KLC1 is vital for neuronal health, as KLC1 supports the transport of essential materials to and from the cell body and axon terminals, which is particularly important in the context of neurodegenerative diseases where transport mechanisms may be compromised. KLC1 monoclonal antibody (L2) is an invaluable tool for researchers studying the dynamics of intracellular transport and the role of kinesin proteins in various biological processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

KLC1 Antibody (L2) References:

1. Defective kinesin heavy chain behavior in mouse kinesin light chain mutants.  |  Rahman, A., et al. 1999. J Cell Biol. 146: 1277-88. PMID: 10491391
2. Kinesin and kinectin can associate with the melanosomal surface and form a link with microtubules in normal human melanocytes.  |  Vancoillie, G., et al. 2000. J Invest Dermatol. 114: 421-9. PMID: 10692099
3. Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement.  |  McDonald, A., et al. 2010. Biochem Soc Trans. 38: 205-8. PMID: 20074060
4. Identification of a novel KLC1-ROS1 fusion in a case of pediatric low-grade localized glioma.  |  Nakano, Y., et al. 2019. Brain Tumor Pathol. 36: 14-19. PMID: 30350109
5. Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.  |  Fukuda, Y., et al. 2021. J Cell Biol. 220: PMID: 33284322
6. Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.  |  Chen, XQ., et al. 2021. Alzheimers Res Ther. 13: 59. PMID: 33691783
7. Primary resistance to ALK inhibitors in KLC1/ALK-rearranged pleural metastatic lung adenocarcinoma: a case report.  |  Siblini, L., et al. 2023. Transl Lung Cancer Res. 12: 2342-2346. PMID: 38090529
8. KLC1-ROS1 Fusion Exerts Oncogenic Properties of Glioma Cells via Specific Activation of JAK-STAT Pathway.  |  Fujii, T., et al. 2023. Cancers (Basel). 16: PMID: 38201436
9. Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing.  |  Kikuchi, M., et al. 2024. Biochem Biophys Res Commun. 721: 150025. PMID: 38768546
10. Expression of neuronal kinesin heavy chain is developmentally regulated in the central nervous system of the rat.  |  Vignali, G., et al. 1997. J Neurochem. 69: 1840-9. PMID: 9349526
11. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins.  |  Rahman, A., et al. 1998. J Biol Chem. 273: 15395-403. PMID: 9624122
12. The C-terminal region of the stalk domain of ubiquitous human kinesin heavy chain contains the binding site for kinesin light chain.  |  Diefenbach, RJ., et al. 1998. Biochemistry. 37: 16663-70. PMID: 9843434

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KLC1 Antibody (L2) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-KLC1 Antibody (L2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KLC1 Antibody (L2) Specifications

Alternate Product Name: KLC1

Product Clone Name: L2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: KLC1

Epitope Species: bovine

Product Reactivity/Detection: KLC1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for KLC1 Antibody (L2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin