KIR7.1 Antibody (C-12): sc-398810

KIR7.1 Antibody (C-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects KIR7.1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-KIR7.1 antibody (C-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KIR7.1, also known as KCNJ13, is a member of the G protein-coupled inwardly rectifying potassium channel family, which plays a crucial role in regulating neuronal excitability and neurotransmitter release. These channels are predominantly located in the soma, dendrites, and axons of neurons, particularly in regions of the brain such as the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex, and thalamus. Proper functioning of KIR7.1 is vital for maintaining the resting membrane potential and modulating synaptic transmission, which is essential for cognitive processes and sensory perception. Additionally, KIR7.1 is subject to various post-translational modifications, including phosphorylation, which can significantly influence channel activity. For instance, tyrosine phosphorylation can inhibit KIR7.1 channel activity, thereby affecting neuronal signaling pathways. Understanding these regulatory mechanisms is important for elucidating the role of KIR7.1 in neurological disorders and developing targeted therapies.

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KIR7.1 Antibody (C-12) References:

1. TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel.  |  Rogalski, SL., et al. 2000. J Biol Chem. 275: 25082-8. PMID: 10833508
2. Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein beta gamma subunits.  |  Lei, Q., et al. 2000. Proc Natl Acad Sci U S A. 97: 9771-6. PMID: 10944236
3. Activation of alpha 1-adrenoceptors modulates the inwardly rectifying potassium currents of mammalian atrial myocytes.  |  Braun, AP., et al. 1992. Pflugers Arch. 421: 431-9. PMID: 1361052
4. G-protein-gated inward rectifier K+ channel proteins (GIRK1) are present in the soma and dendrites as well as in nerve terminals of specific neurons in the brain.  |  Ponce, A., et al. 1996. J Neurosci. 16: 1990-2001. PMID: 8604043
5. Neurotensin and dopamine D2 activation oppositely regulate the same K+ conductance in rat midbrain dopaminergic neurons.  |  Farkas, RH., et al. 1997. Neurosci Lett. 231: 21-4. PMID: 9280158

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KIR7.1 Antibody (C-12) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-KIR7.1 Antibody (C-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KIR7.1 Antibody (C-12) Specifications

Alternate Product Name: KIR7.1

Product Clone Name: C-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 287-360

Epitope Target: KIR7.1

Epitope Species: human

Product Reactivity/Detection: KIR7.1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for KIR7.1 Antibody (C-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin