KIR3DL1/2 Antibody (G-4): sc-398824

KIR3DL1/2 Antibody (G-4) is a mouse monoclonal IgG2b antibody that detects KIR3DL1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KIR3DL1/2 antibody (G-4) plays a crucial role in the immune response by recognizing human leukocyte antigen (HLA) class I molecules, specifically targeting HLA-B antigens with the Bw4 allele, which is essential for regulating the activation and inhibition of natural killer (NK) cell responses. KIR3DL1 is a type I transmembrane protein composed of 444 amino acids and features three immunoglobulin-like C2-type domains, which are vital for its function in transmitting inhibitory signals to prevent NK cell-mediated cytotoxicity. KIR3DL1 monoclonal antibody (G-4) helps identify proteins crucial for maintaining immune tolerance and preventing autoimmunity, as KIR3DL1 helps to distinguish between healthy and infected or transformed cells. Additionally, KIR3DL1 and its related receptor KIR3DL2 are located on chromosome 19, highlighting their genetic significance in immune regulation.

The preferred KIR3DL1 antibody is KIR3DL1 Antibody (B-8): sc-377220.