KIR2DL1 Antibody (JJ C11.6): sc-53595

KIR2DL1 Antibody (JJ C11.6) is a mouse monoclonal IgG1 kappa light chain antibody that detects the KIR2DL1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). KIR2DL1 (JJ C11.6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The KIR2DL1 protein plays a crucial role in the immune response by downregulating the cytotoxic activity of natural killer (NK) cells when recognizing specific class I major histocompatibility complex (MHC) molecules on target cells. This interaction is vital for maintaining self-tolerance and preventing autoimmunity, as KIR2DL1 helps to distinguish between healthy and infected or transformed cells. Structurally, KIR2DL1 is a type I transmembrane protein composed of 348 amino acids, featuring an extracellular region with immunoglobulin-like domains that facilitate binding to human leukocyte antigen-C (HLA-C). The binding occurs through a specific pocket that coordinates key residues, allowing for both polar and hydrophobic interactions, which are essential for the receptor′s function. Anti-KIR2DL1 antibody (JJ C11.6) is an invaluable tool for researchers studying NK cell regulation and the intricate mechanisms of immune evasion by tumors and pathogens.

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KIR2DL1 Antibody (JJ C11.6) References:

1. A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer.  |  Fan, QR., et al. 2000. Eur J Immunol. 30: 2692-7. PMID: 11009104
2. Detection of autoantibodies to killer immunoglobulin-like receptors using recombinant fusion proteins for two killer immunoglobulin-like receptors in patients with systemic autoimmune diseases.  |  Matsui, T., et al. 2001. Arthritis Rheum. 44: 384-8. PMID: 11229470
3. Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex.  |  Fan, QR., et al. 2001. Nat Immunol. 2: 452-60. PMID: 11323700
4. Recognition of HLA-Cw4 but not HLA-Cw6 by the NK cell receptor killer cell Ig-like receptor two-domain short tail number 4.  |  Katz, G., et al. 2001. J Immunol. 166: 7260-7. PMID: 11390475
5. Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis.  |  Maeda, N., et al. 2002. Fertil Steril. 77: 297-302. PMID: 11821086
6. Reduced KIR2DL1 recognition of MHC class I molecules presenting phosphorylated peptides.  |  Betser-Cohen, G., et al. 2006. J Immunol. 176: 6762-9. PMID: 16709835
7. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells.  |  Colonna, M. and Samaridis, J. 1995. Science. 268: 405-8. PMID: 7716543
8. Chromosomal localization of the human natural killer cell class I receptor family genes to 19q13.4 by fluorescence in situ hybridization.  |  Suto, Y., et al. 1996. Genomics. 35: 270-2. PMID: 8661137
9. Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition.  |  Winter, CC., et al. 1998. J Immunol. 161: 571-7. PMID: 9670929

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KIR2DL1 Antibody (JJ C11.6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-KIR2DL1 Antibody (JJ C11.6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KIR2DL1 Antibody (JJ C11.6) Specifications

Alternate Product Name: KIR2DL1

Product Clone Name: JJ C11.6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: KIR2DL1

Epitope Species: human

Product Reactivity/Detection: KIR2DL1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for KIR2DL1 Antibody (JJ C11.6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred KIR3DL1 antibody is KIR3DL1 Antibody (B-8): sc-377220.