Kininogen LC Antibody (C11C1): sc-23915
- Kininogen LC Antibody (C11C1) is a mouse monoclonal IgG1 κ Kininogen LC antibody provided at 200 µg/ml
- raised against purified high molecular weight Kininogen (HMWK) of human origin
- Kininogen LC Antibody (C11C1) is recommended for detection of unique Kinonogen light chain of human origin by WB, IP, IF and IHC(P)
- Anti-Kininogen LC Antibody (C11C1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Kininogen LC Antibody (C11C1) for WB and IHC(P) applications. These reagents are now offered in bundles with Kininogen LC Antibody (C11C1) (see ordering information below).
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Kininogen LC Antibody (C11C1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Kininogen LC protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Kininogen LC antibody (C11C1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Kininogen is a 644 amino acid precursor protein encoded by the KNG1 gene and is secreted into blood plasma, where Kininogen plays a crucial role in regulating hemostasis and inflammation. Kininogen undergoes alternative splicing, resulting in the production of Kininogen LC and Kininogen HC, each with distinct biological functions. Kininogen LC serves as a potent inhibitor of cysteine proteinases and plays a significant role in preventing thrombocyte aggregation, thereby contributing to the maintenance of vascular integrity. Kininogen HC is involved in blood coagulation, facilitating the interaction of prekallikrein and Factor XI with Factor XII, and Kininogen HC releases bradykinin, a peptide that mediates various physiological responses, including smooth muscle contraction and inflammatory processes. Kininogen LC′s ability to modulate these interactions highlights Kininogen LC′s importance in maintaining homeostasis and regulating inflammatory responses within the human body.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Kininogen LC Antibody (C11C1) References:
- Release of a new vascular permeability enhancing peptide from kininogens by human neutrophil elastase. | Imamura, T., et al. 2002. Biochem Biophys Res Commun. 294: 423-8. PMID: 12051729
- The T-kininogen, T-kinin system of the rat. | Greenbaum, LM. 1992. Agents Actions Suppl. 36: 215-22. PMID: 1609645
- Chromosomal mapping of human kininogen gene (KNG) to 3q26----qter. | Cheung, PP., et al. 1992. Cytogenet Cell Genet. 59: 24-6. PMID: 1733668
- Structural organization of the human kininogen gene and a model for its evolution. | Kitamura, N., et al. 1985. J Biol Chem. 260: 8610-7. PMID: 2989294
- Kallikrein, kininogen and kinins in control of blood pressure. | Mills, IH. 1979. Nephron. 23: 61-71. PMID: 375113
- Role of bovine high-molecular-weight (HMW) kininogen in contact-mediated activation of bovine Factor XII. | Kato, H., et al. 1979. Adv Exp Med Biol. 120B: 19-37. PMID: 390983
- The role of high molecular weight kininogen in contact activation of coagulation, fibrinolysis and kinin generation. | Kaplan, AP. 1979. Adv Exp Med Biol. 120B: 71-91. PMID: 390992
- Molecular aspects of kallikrein and kininogen in the maturing kidney. | el-Dahr, SS. and Dipp, S. 1993. Pediatr Nephrol. 7: 646-51. PMID: 8251340
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Kininogen LC Antibody (C11C1) | sc-23915 | 200 µg/ml | $316.00 | |||
Kininogen LC Antibody (C11C1): m-IgG Fc BP-HRP Bundle | sc-528381 | 200 µg Ab; 10 µg BP | $354.00 | |||
Kininogen LC Antibody (C11C1): m-IgGκ BP-HRP Bundle | sc-520746 | 200 µg Ab, 40 µg BP | $354.00 | |||
Kininogen LC Antibody (C11C1): m-IgG1 BP-HRP Bundle | sc-542908 | 200 µg Ab; 20 µg BP | $354.00 | |||
Kininogen LC Antibody (C11C1) AC | sc-23915 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Kininogen LC Antibody (C11C1) HRP | sc-23915 HRP | 200 µg/ml | $316.00 | |||
Kininogen LC Antibody (C11C1) FITC | sc-23915 FITC | 200 µg/ml | $330.00 | |||
Kininogen LC Antibody (C11C1) PE | sc-23915 PE | 200 µg/ml | $343.00 | |||
Kininogen LC Antibody (C11C1) Alexa Fluor® 488 | sc-23915 AF488 | 200 µg/ml | $357.00 | |||
Kininogen LC Antibody (C11C1) Alexa Fluor® 546 | sc-23915 AF546 | 200 µg/ml | $357.00 | |||
Kininogen LC Antibody (C11C1) Alexa Fluor® 594 | sc-23915 AF594 | 200 µg/ml | $357.00 | |||
Kininogen LC Antibody (C11C1) Alexa Fluor® 647 | sc-23915 AF647 | 200 µg/ml | $357.00 | |||
Kininogen LC Antibody (C11C1) Alexa Fluor® 680 | sc-23915 AF680 | 200 µg/ml | $357.00 | |||
Kininogen LC Antibody (C11C1) Alexa Fluor® 790 | sc-23915 AF790 | 200 µg/ml | $357.00 |