KIAA0753 Antibody (B-3): sc-398879
- KIAA0753 Antibody (B-3) is a mouse monoclonal IgG1 κ KIAA0753 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 341-373 within an internal region of KIAA0753 of human origin
- KIAA0753 Antibody (B-3) is recommended for detection of KIAA0753 of human origin, 4933427D14Rik of mouse origin and the corresponding rat homolog by WB, IP, IF and ELISA
- Anti-KIAA0753 Antibody (B-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KIAA0753 Antibody (B-3) for WB applications. These reagents are now offered in bundles with KIAA0753 Antibody (B-3) (see ordering information below).
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KIAA0753 Antibody (B-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects KIAA0753 protein of human origin, 4933427D14Rik protein of mouse origin, and the corresponding rat homolog by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KIAA0753 (B-3) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KIAA0753 protein consists of 967 amino acids, features a coiled-coil domain and exists in two alternatively spliced isoforms, which may have distinct functional roles in cellular processes. KIAA0753 is involved in cellular signaling pathways that regulate cell proliferation and differentiation, making KIAA0753 crucial for maintaining normal cellular functions and preventing tumorigenesis. KIAA0753 gene is located on human chromosome 17, a region comprising over 2.5% of the human genome and associated with key tumor suppressor genes such as p53 and BRCA1, which are vital for DNA repair and maintaining genomic stability. KIAA0753 interactions with these tumor suppressors suggests potential involvement in cancer biology, as functional disruptions could contribute to malignancy development. Understanding KIAA0753 dynamics and interactions within cellular environments can provide insights into therapeutic strategies for cancer and chromosomal abnormality-related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KIAA0753 Antibody (B-3) References:
- Birt-Hogg-Dubé Syndrome. | Welsch, MJ., et al. 2005. Int J Dermatol. 44: 668-73. PMID: 16101870
- BLIMP1 regulates cell growth through repression of p53 transcription. | Yan, J., et al. 2007. Proc Natl Acad Sci U S A. 104: 1841-6. PMID: 17264218
- Neurofibromatosis 1, and Not TP53, seems to be the main target of chromosome 17 deletions in de novo acute myeloid leukemia. | Suela, J., et al. 2007. J Clin Oncol. 25: 1151-2; author reply 1152-3. PMID: 17369586
- Quantification of N-acetylaspartic acid in urine by LC-MS/MS for the diagnosis of Canavan disease. | Al-Dirbashi, OY., et al. 2007. J Inherit Metab Dis. 30: 612. PMID: 17632691
- Susceptibility to breast cancer: hereditary syndromes and low penetrance genes. | Nusbaum, R., et al. Breast Dis. 27: 21-50. PMID: 17917139
- Genetic causes of brain tumors: neurofibromatosis, tuberous sclerosis, von Hippel-Lindau, and other syndromes. | Farrell, CJ. and Plotkin, SR. 2007. Neurol Clin. 25: 925-46, viii. PMID: 17964021
- The full-ORF clone resource of the German cDNA Consortium. | Bechtel, S., et al. 2007. BMC Genomics. 8: 399. PMID: 17974005
- Breast cancer risk among male BRCA1 and BRCA2 mutation carriers. | Tai, YC., et al. 2007. J Natl Cancer Inst. 99: 1811-4. PMID: 18042939
- Novel deletion mutation in GFAP gene in an infantile form of Alexander disease. | Murakami, N., et al. 2008. Pediatr Neurol. 38: 50-2. PMID: 18054694
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KIAA0753 Antibody (B-3) | sc-398879 | 200 µg/ml | $322.00 | |||
KIAA0753 Antibody (B-3): m-IgG Fc BP-HRP Bundle | sc-530953 | 200 µg Ab; 10 µg BP | $361.00 | |||
KIAA0753 Antibody (B-3): m-IgGκ BP-HRP Bundle | sc-524519 | 200 µg Ab, 40 µg BP | $361.00 | |||
KIAA0753 Antibody (B-3): m-IgG1 BP-HRP Bundle | sc-544334 | 200 µg Ab; 20 µg BP | $361.00 | |||
KIAA0753 Antibody (B-3) AC | sc-398879 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KIAA0753 Antibody (B-3) HRP | sc-398879 HRP | 200 µg/ml | $322.00 | |||
KIAA0753 Antibody (B-3) FITC | sc-398879 FITC | 200 µg/ml | $336.00 | |||
KIAA0753 Antibody (B-3) PE | sc-398879 PE | 200 µg/ml | $349.00 | |||
KIAA0753 Antibody (B-3) Alexa Fluor® 488 | sc-398879 AF488 | 200 µg/ml | $364.00 | |||
KIAA0753 Antibody (B-3) Alexa Fluor® 546 | sc-398879 AF546 | 200 µg/ml | $364.00 | |||
KIAA0753 Antibody (B-3) Alexa Fluor® 594 | sc-398879 AF594 | 200 µg/ml | $364.00 | |||
KIAA0753 Antibody (B-3) Alexa Fluor® 647 | sc-398879 AF647 | 200 µg/ml | $364.00 | |||
KIAA0753 Antibody (B-3) Alexa Fluor® 680 | sc-398879 AF680 | 200 µg/ml | $364.00 | |||
KIAA0753 Antibody (B-3) Alexa Fluor® 790 | sc-398879 AF790 | 200 µg/ml | $364.00 | |||
KIAA0753 (B-3) Neutralizing Peptide | sc-398879 P | 100 µg/0.5 ml | $69.00 |