KCNH5 Antibody (A-8): sc-398458

KCNH5 Antibody (A-8) is a mouse monoclonal IgG1 antibody that detects KCNH5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KCNH5, also known as potassium voltage-gated channel subfamily H member 5 or human ether-a-go-go potassium channel 2 (hEAG2), is a crucial α subunit of a multi-pass transmembrane potassium channel that plays a significant role in regulating cellular excitability within the nervous system. The structure of KCNH5 is particularly important as KCNH5 forms the pore of the voltage-gated channel, which can exist as a homo- or heterotetrameric assembly of α subunits, often in conjunction with modulating β subunits. This structural configuration is vital for the channel′s function, as KCNH5 allows for precise control over ion flow across the cell membrane, influencing membrane potential and the generation of action potentials. KCNH5 is expressed in various tissues, including the brain, skeletal muscle, heart, placenta, lung, and liver, highlighting KCNH5′s essential role in diverse physiological processes. Anti-KCNH5 antibody (A-8) is an invaluable tool for researchers studying the dynamics of potassium channels and their implications in cellular excitability and related disorders.

The preferred KCNH5 antibody is KCNH5 Antibody (A-6): sc-393777.