KCNH5 Antibody (A-6): sc-393777
- KCNH5 Antibody (A-6) is a mouse monoclonal IgG1 κ KCNH5 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 959-984 within a C-terminal cytoplasmic domain of KCNH5 of human origin
- KCNH5 Antibody (A-6) is recommended for detection of KCNH5 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-KCNH5 Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KCNH5 Antibody (A-6) for WB applications. These reagents are now offered in bundles with KCNH5 Antibody (A-6) (see ordering information below).
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KCNH5 Antibody (A-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects KCNH5 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KCNH5 (A-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KCNH5, also known as potassium voltage-gated channel subfamily H member 5 or human ether-a-go-go potassium channel 2 (hEAG2), plays a critical role in regulating cellular excitability, particularly in the nervous system. KCNH5 functions as the α subunit of a multi-pass transmembrane potassium channel, which is essential for forming the channel′s pore. KCNH5′s structure is significant because KCNH5 can exist as a homo- or heterotetramer, allowing for diverse functional properties through association with modulating β subunits. This structural versatility is crucial for KCNH5′s ability to adapt to various physiological conditions, influencing membrane potential and action potential dynamics. KCNH5 is expressed in a wide range of tissues, including brain, skeletal muscle, heart, placenta, lung, liver, and, to a lesser extent, kidney, highlighting KCNH5′s importance in multiple biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KCNH5 Antibody (A-6) References:
- Functional distinction of human EAG1 and EAG2 potassium channels. | Schönherr, R., et al. 2002. FEBS Lett. 514: 204-8. PMID: 11943152
- Molecular identification and characterisation of the human eag2 potassium channel. | Ju, M. and Wray, D. 2002. FEBS Lett. 524: 204-10. PMID: 12135768
- Molecular regions responsible for differences in activation between heag channels. | Ju, M. and Wray, D. 2006. Biochem Biophys Res Commun. 342: 1088-97. PMID: 16513085
- Neural differentiation of human mesenchymal stem cells: Evidence for expression of neural markers and eag K+ channel types. | Mareschi, K., et al. 2006. Exp Hematol. 34: 1563-72. PMID: 17046576
- Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. | Occhiodoro, T., et al. 1998. FEBS Lett. 434: 177-82. PMID: 9738473
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KCNH5 Antibody (A-6) | sc-393777 | 200 µg/ml | $322.00 | |||
KCNH5 Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-530576 | 200 µg Ab; 10 µg BP | $361.00 | |||
KCNH5 Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-524084 | 200 µg Ab, 40 µg BP | $361.00 | |||
KCNH5 Antibody (A-6): m-IgG1 BP-HRP Bundle | sc-544140 | 200 µg Ab; 20 µg BP | $361.00 | |||
KCNH5 Antibody (A-6) AC | sc-393777 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KCNH5 Antibody (A-6) HRP | sc-393777 HRP | 200 µg/ml | $322.00 | |||
KCNH5 Antibody (A-6) FITC | sc-393777 FITC | 200 µg/ml | $336.00 | |||
KCNH5 Antibody (A-6) PE | sc-393777 PE | 200 µg/ml | $349.00 | |||
KCNH5 Antibody (A-6) Alexa Fluor® 488 | sc-393777 AF488 | 200 µg/ml | $364.00 | |||
KCNH5 Antibody (A-6) Alexa Fluor® 546 | sc-393777 AF546 | 200 µg/ml | $364.00 | |||
KCNH5 Antibody (A-6) Alexa Fluor® 594 | sc-393777 AF594 | 200 µg/ml | $364.00 | |||
KCNH5 Antibody (A-6) Alexa Fluor® 647 | sc-393777 AF647 | 200 µg/ml | $364.00 | |||
KCNH5 Antibody (A-6) Alexa Fluor® 680 | sc-393777 AF680 | 200 µg/ml | $364.00 | |||
KCNH5 Antibody (A-6) Alexa Fluor® 790 | sc-393777 AF790 | 200 µg/ml | $364.00 | |||
KCNH5 (A-6) Neutralizing Peptide | sc-393777 P | 100 µg/0.5 ml | $69.00 |