KBP Antibody (H-12): sc-390449
- KBP Antibody (H-12) is a mouse monoclonal IgG2b κ KBP antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 380-394 within an internal region of KBP of human origin
- KBP Antibody (H-12) is recommended for detection of KBP of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- Anti-KBP Antibody (H-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KBP Antibody (H-12) for WB applications. These reagents are now offered in bundles with KBP Antibody (H-12) (see ordering information below).
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KBP Antibody (H-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects KBP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KBP Antibody (H-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KBP protein, also known as KIF1-binding protein or KIAA1279, is a crucial 621 amino acid mitochondrial protein predominantly expressed in heart, brain, ovary, testis, and spinal cord, with lower expression levels in most adult tissues. KBP plays a vital role in mitochondrial transport by modulating KIF1B motor activity, which is essential for proper distribution of mitochondria within cells. Additionally, KBP is necessary for axonal microtubule organization and maintenance of axonal growth during development of both peripheral and central nervous systems. KBP gene is located on human chromosome 10q21.3 and mouse chromosome 10 B4, and mutations in KBP gene have been associated with Goldberg-Shprintzen megacolon syndrome, a neurological disorder characterized by microcephaly, mental retardation, and facial dysmorphism.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KBP Antibody (H-12) References:
- Homozygous nonsense mutations in KIAA1279 are associated with malformations of the central and enteric nervous systems. | Brooks, AS., et al. 2005. Am J Hum Genet. 77: 120-6. PMID: 15883926
- The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein. | Wozniak, MJ., et al. 2005. BMC Cell Biol. 6: 35. PMID: 16225668
- Two brothers with Goldberg-Shprintzen syndrome. | Murphy, HR., et al. 2006. Clin Dysmorphol. 15: 165-169. PMID: 16760737
- KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome. | Lyons, DA., et al. 2008. Development. 135: 599-608. PMID: 18192286
- Cortical brain malformations: effect of clinical, neuroradiological, and modern genetic classification. | de Wit, MC., et al. 2008. Arch Neurol. 65: 358-66. PMID: 18332248
- Copy number variants in candidate genes are genetic modifiers of Hirschsprung disease. | Jiang, Q., et al. 2011. PLoS One. 6: e21219. PMID: 21712996
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KBP Antibody (H-12) | sc-390449 | 200 µg/ml | $322.00 | |||
KBP Antibody (H-12): m-IgG Fc BP-HRP Bundle | sc-530160 | 200 µg Ab; 10 µg BP | $361.00 | |||
KBP Antibody (H-12): m-IgGκ BP-HRP Bundle | sc-523537 | 200 µg Ab, 40 µg BP | $361.00 | |||
KBP Antibody (H-12) AC | sc-390449 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KBP Antibody (H-12) HRP | sc-390449 HRP | 200 µg/ml | $322.00 | |||
KBP Antibody (H-12) FITC | sc-390449 FITC | 200 µg/ml | $336.00 | |||
KBP Antibody (H-12) PE | sc-390449 PE | 200 µg/ml | $349.00 | |||
KBP Antibody (H-12) Alexa Fluor® 488 | sc-390449 AF488 | 200 µg/ml | $364.00 | |||
KBP Antibody (H-12) Alexa Fluor® 546 | sc-390449 AF546 | 200 µg/ml | $364.00 | |||
KBP Antibody (H-12) Alexa Fluor® 594 | sc-390449 AF594 | 200 µg/ml | $364.00 | |||
KBP Antibody (H-12) Alexa Fluor® 647 | sc-390449 AF647 | 200 µg/ml | $364.00 | |||
KBP Antibody (H-12) Alexa Fluor® 680 | sc-390449 AF680 | 200 µg/ml | $364.00 | |||
KBP Antibody (H-12) Alexa Fluor® 790 | sc-390449 AF790 | 200 µg/ml | $364.00 | |||
KBP (H-12) Neutralizing Peptide | sc-390449 P | 100 µg/0.5 ml | $69.00 |