karyopherin β3 Antibody (E-4): sc-17801

karyopherin β3 Antibody (E-4) is a mouse monoclonal IgG2a antibody that detects karyopherin β3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Karyopherin β3 plays a crucial role in the nuclear import of proteins, particularly those involved in ribosome assembly and function, which is essential for maintaining cellular homeostasis and protein synthesis. By facilitating the transport of ribosomal proteins into the nucleus, karyopherin β3 ensures that the ribosomal subunits are properly assembled and available for translation processes in the cytoplasm. This transport mechanism is vital for cellular growth and proliferation, as ribosomes are the cellular machinery responsible for synthesizing proteins that perform a myriad of functions within the cell. Anti-karyopherin β3 antibody (E-4) is an invaluable tool for researchers studying the dynamics of nuclear transport and its implications in various biological processes and diseases, including cancer, where dysregulation of protein import can lead to aberrant cell growth and function.

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karyopherin β3 Antibody (E-4) References:

1. Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.  |  Neumann, M., et al. 2012. Acta Neuropathol. 124: 705-16. PMID: 22842875
2. Transportin 1 colocalization with Fused in Sarcoma (FUS) inclusions is not characteristic for amyotrophic lateral sclerosis-FUS confirming disrupted nuclear import of mutant FUS and distinguishing it from frontotemporal lobar degeneration with FUS inclusions.  |  Troakes, C., et al. 2013. Neuropathol Appl Neurobiol. 39: 553-61. PMID: 22934812
3. Redox-dependent control of FOXO/DAF-16 by transportin-1.  |  Putker, M., et al. 2013. Mol Cell. 49: 730-42. PMID: 23333309
4. Transportin-1-dependent YB-1 nuclear import.  |  Mordovkina, DA., et al. 2016. Biochem Biophys Res Commun. 480: 629-634. PMID: 27794479
5. Influenza virus uses transportin 1 for vRNP debundling during cell entry.  |  Miyake, Y., et al. 2019. Nat Microbiol. 4: 578-586. PMID: 30692667
6. Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating.  |  Fernandez, J., et al. 2019. Nat Microbiol. 4: 1840-1850. PMID: 31611641
7. Nup358 and Transportin 1 Cooperate in Adenoviral Genome Import.  |  Carlon-Andres, I., et al. 2020. J Virol. 94: PMID: 32161167
8. Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation.  |  Lenard, AJ., et al. 2021. Front Mol Biosci. 8: 689687. PMID: 34738012
9. Tumor suppressor BAP1 nuclear import is governed by transportin-1.  |  Yang, TJ., et al. 2022. J Cell Biol. 221: PMID: 35446349
10. Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein.  |  Pörschke, M., et al. 2023. J Biol Chem. 299: 102932. PMID: 36690276

The preferred karyopherin β3 antibody is karyopherin β3 Antibody (B-7): sc-55527.