karyopherin α2 Antibody (G-7): sc-514663

karyopherin α2 Antibody (G-7) is a mouse monoclonal IgG2b antibody that detects karyopherin α2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Karyopherin α2 plays a crucial role in the nuclear import process, specifically in recognizing and binding to substrates destined for transport into the nucleus. Karyopherin α2 ensures selective transport of various proteins, including transcription factors and regulatory proteins, which maintain cellular function and gene expression. Anti-karyopherin α2 antibody (G-7) recognizes specific substrates that regulate cellular processes such as growth, differentiation, and response to stress. Karyopherin α2 has been shown to complex with Epstein-Barr virus nuclear antigen 1 (EBNA1), highlighting its importance in normal cellular function and viral pathogenesis. Karyopherin α2 monoclonal antibody (G-7) enables researchers to study nuclear transport mechanisms and their implications in health and disease.

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karyopherin α2 Antibody (G-7) References:

1. Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import.  |  Zannini, L., et al. 2003. J Biol Chem. 278: 42346-51. PMID: 12909615
2. Nuclear transport receptor karyopherin-α2 promotes malignant breast cancer phenotypes in vitro.  |  Noetzel, E., et al. 2012. Oncogene. 31: 2101-14. PMID: 21909132
3. Karyopherin alpha2 is essential for rRNA transcription and protein synthesis in proliferative keratinocytes.  |  Umegaki-Arao, N., et al. 2013. PLoS One. 8: e76416. PMID: 24098495
4. Upregulated Expression of Karyopherin α2 is Involved in Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats.  |  Xu, Z., et al. 2016. Cell Mol Neurobiol. 36: 755-65. PMID: 26340948
5. Karyopherin α2 induces apoptosis in tongue squamous cell carcinoma CAL-27 cells through the p53 pathway.  |  Gao, L., et al. 2016. Oncol Rep. 35: 3357-62. PMID: 27109484
6. Overexpression of karyopherin-α2 in cholangiocarcinoma correlates with poor prognosis and gemcitabine sensitivity via nuclear translocation of DNA repair proteins.  |  Tsukagoshi, M., et al. 2017. Oncotarget. 8: 42159-42172. PMID: 28178675
7. Enhanced karyopherin-α2 expression is associated with carcinogenesis in patients with intraductal papillary mucinous neoplasms.  |  Kubo, N., et al. 2017. Pancreatology. 17: 611-616. PMID: 28476582
8. Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer.  |  Drucker, E., et al. 2019. Cell Commun Signal. 17: 159. PMID: 31783876
9. Long non-coding RNA HAGLROS facilitates tumorigenesis and progression in hepatocellular carcinoma by sponging miR-26b-5p to up-regulate karyopherin α2 (KPNA2) and inactivate p53 signaling.  |  Tang, G., et al. 2022. Bioengineered. 13: 7829-7846. PMID: 35291921
10. Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2.  |  Fischer, N., et al. 1997. J Biol Chem. 272: 3999-4005. PMID: 9020106

The preferred karyopherin α2 antibody is karyopherin α2 Antibody (B-9): sc-55538.