karyopherin α2 Antibody (G-11): sc-55537

karyopherin α2 Antibody (G-11) is a mouse monoclonal IgG2b antibody that detects karyopherin α2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Karyopherin α2 plays a crucial role in the nuclear import process by recognizing and binding to specific substrates, which is essential for the regulation of gene expression and cellular function. Karyopherin α2 is primarily located in the cytoplasm, where karyopherin α2 interacts with various nuclear localization signals on cargo proteins, facilitating their transport across the nuclear envelope. Karyopherin α2′s location enables efficient and selective protein import into the nucleus, thereby maintaining cellular homeostasis and responding to environmental signals. Additionally, karyopherin α2 forms complexes with viral proteins, such as the Epstein-Barr virus nuclear antigen 1 (EBNA1), highlighting karyopherin α2′s role in both normal cellular processes and viral pathogenesis. Anti-karyopherin α2 antibody (G-11) serves as an invaluable tool for researchers studying nuclear transport mechanisms and their implications in health and disease.

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karyopherin α2 Antibody (G-11) References:

1. Epstein-barr virus nuclear antigen-1 binds to nuclear transporter karyopherin alpha1/NPI-1 in addition to karyopherin alpha2/Rch1.  |  Ito, S., et al. 2000. Virology. 266: 110-9. PMID: 10612665
2. Genomic structure of karyopherin alpha2 (KPNA2) within a low-copy repeat on chromosome 17q23-q24 and mutation analysis in patients with Russell-Silver syndrome.  |  Dörr, SN., et al. 2001. Hum Genet. 109: 479-86. PMID: 11735022
3. Nuclear karyopherin alpha2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity.  |  Gluz, O., et al. 2008. Int J Cancer. 123: 1433-8. PMID: 18561322
4. High expression of karyopherin-α2 defines poor prognosis in non-muscle-invasive bladder cancer and in patients with invasive bladder cancer undergoing radical cystectomy.  |  Jensen, JB., et al. 2011. Eur Urol. 59: 841-8. PMID: 21330047
5. Nuclear transport receptor karyopherin-α2 promotes malignant breast cancer phenotypes in vitro.  |  Noetzel, E., et al. 2012. Oncogene. 31: 2101-14. PMID: 21909132
6. Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin α2/β1 heterodimer.  |  Sturchler, E., et al. 2013. Biochim Biophys Acta. 1833: 583-92. PMID: 23123190
7. Nuclear karyopherin-α2 expression in primary lesions and metastatic lymph nodes was associated with poor prognosis and progression in gastric cancer.  |  Altan, B., et al. 2013. Carcinogenesis. 34: 2314-21. PMID: 23749771
8. Upregulated Expression of Karyopherin α2 is Involved in Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats.  |  Xu, Z., et al. 2016. Cell Mol Neurobiol. 36: 755-65. PMID: 26340948
9. High expression of karyopherin-α2 and stathmin 1 is associated with proliferation potency and transformation in the bile duct and gall bladder epithelia in the cases of pancreaticobiliary maljunction.  |  Saito, F., et al. 2016. J Surg Oncol. 114: 462-8. PMID: 27338241
10. Overexpression of karyopherin-α2 in cholangiocarcinoma correlates with poor prognosis and gemcitabine sensitivity via nuclear translocation of DNA repair proteins.  |  Tsukagoshi, M., et al. 2017. Oncotarget. 8: 42159-42172. PMID: 28178675

The preferred karyopherin α2 antibody is karyopherin α2 Antibody (B-9): sc-55538.