karyopherin 13 Antibody (D-8): sc-393661

karyopherin 13 Antibody (D-8) is a mouse monoclonal IgG1 antibody that detects karyopherin 13 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Karyopherin 13, also known as Importin-13 or Ran-binding protein 13, is a crucial nuclear transport receptor composed of 963 amino acids, featuring twenty HEAT repeats and one importin N-terminal domain. Karyopherin 13 plays a vital role in nuclear import and export processes, facilitating the transport of various cargo substrates, including UBC9, the RBM8A/MAGOH complex, Pax-6, eIF1AY, and Ran, which are essential for numerous cellular functions. Karyopherin 13′s ability to mediate nuclear localization of these proteins is particularly important for regulating gene expression and maintaining cellular homeostasis. Karyopherin 13 is expressed in key tissues such as the fetal brain, heart, intestine, and kidney, and its localization to both the nucleus and cytoplasm underscores its multifaceted role in cellular transport mechanisms. The gene encoding karyopherin 13 is located on human chromosome 1p34.1 and mouse chromosome 4 D2.1, highlighting its evolutionary conservation and significance across species.

The preferred karyopherin 13 antibody is karyopherin 13 Antibody (D-3): sc-271218.