karyopherin 13 Antibody (D-3): sc-271218
- karyopherin 13 Antibody (D-3) is a mouse monoclonal IgG1 κ karyopherin 13 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 129-177 within an internal region of karyopherin 13 of human origin
- karyopherin 13 Antibody (D-3) is recommended for detection of karyopherin 13 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine and porcine
- Anti-karyopherin 13 Antibody (D-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for karyopherin 13 Antibody (D-3) for WB and IHC(P) applications. These reagents are now offered in bundles with karyopherin 13 Antibody (D-3) (see ordering information below).
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karyopherin 13 Antibody (D-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects karyopherin 13 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). karyopherin 13 Antibody (D-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Karyopherin 13, also known as Importin-13 or IPO13, is a crucial protein belonging to the importin beta family, consisting of 963 amino acids and characterized by twenty HEAT repeats and one importin N-terminal domain. This protein is primarily located in the nucleus and cytoplasm, with significant expression in fetal brain, heart, intestine, and kidney tissues. Karyopherin 13 plays a vital role as a nuclear transport receptor, facilitating the import of proteins into the nucleus by recognizing nuclear localization signals in cargo substrates, which is essential for regulating various cellular processes. Notably, karyopherin 13 is involved in the nuclear import and export of several key proteins, including UBC9, the RBM8A/MAGOH complex, Pax-6, eIF1AY, and Ran, highlighting its importance in cellular signaling and gene expression regulation. The gene encoding karyopherin 13 is mapped to human chromosome 1p34.1 and mouse chromosome 4 D2.1, underscoring its evolutionary conservation and significance across species.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
karyopherin 13 Antibody (D-3) References:
- A novel karyopherin-beta homolog is developmentally and hormonally regulated in fetal lung. | Zhang, C., et al. 2000. Am J Respir Cell Mol Biol. 22: 451-9. PMID: 10745026
- Importin 13: a novel mediator of nuclear import and export. | Mingot, JM., et al. 2001. EMBO J. 20: 3685-94. PMID: 11447110
- Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13. | Ploski, JE., et al. 2004. Mol Cell Biol. 24: 4824-34. PMID: 15143176
- Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13. | Bono, F., et al. 2010. Mol Cell. 37: 211-22. PMID: 20122403
- Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation. | Grünwald, M. and Bono, F. 2011. EMBO J. 30: 427-38. PMID: 21139563
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. | Nagase, T., et al. 1998. DNA Res. 5: 277-86. PMID: 9872452
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
karyopherin 13 Antibody (D-3) | sc-271218 | 200 µg/ml | $322.00 | |||
karyopherin 13 Antibody (D-3): m-IgG Fc BP-HRP Bundle | sc-529142 | 200 µg Ab; 10 µg BP | $361.00 | |||
karyopherin 13 Antibody (D-3): m-IgGκ BP-HRP Bundle | sc-521881 | 200 µg Ab, 40 µg BP | $361.00 | |||
karyopherin 13 Antibody (D-3): m-IgG1 BP-HRP Bundle | sc-543348 | 200 µg Ab; 20 µg BP | $361.00 | |||
karyopherin 13 Antibody (D-3) AC | sc-271218 AC | 500 µg/ml, 25% agarose | $424.00 | |||
karyopherin 13 Antibody (D-3) HRP | sc-271218 HRP | 200 µg/ml | $322.00 | |||
karyopherin 13 Antibody (D-3) FITC | sc-271218 FITC | 200 µg/ml | $336.00 | |||
karyopherin 13 Antibody (D-3) PE | sc-271218 PE | 200 µg/ml | $349.00 | |||
karyopherin 13 Antibody (D-3) Alexa Fluor® 488 | sc-271218 AF488 | 200 µg/ml | $364.00 | |||
karyopherin 13 Antibody (D-3) Alexa Fluor® 546 | sc-271218 AF546 | 200 µg/ml | $364.00 | |||
karyopherin 13 Antibody (D-3) Alexa Fluor® 594 | sc-271218 AF594 | 200 µg/ml | $364.00 | |||
karyopherin 13 Antibody (D-3) Alexa Fluor® 647 | sc-271218 AF647 | 200 µg/ml | $364.00 | |||
karyopherin 13 Antibody (D-3) Alexa Fluor® 680 | sc-271218 AF680 | 200 µg/ml | $364.00 | |||
karyopherin 13 Antibody (D-3) Alexa Fluor® 790 | sc-271218 AF790 | 200 µg/ml | $364.00 | |||
karyopherin 13 (D-3) Neutralizing Peptide | sc-271218 P | 100 µg/0.5 ml | $69.00 |