κB-Ras1 Antibody (C-7): sc-398511

κB-Ras1 Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects κB-Ras1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). κB-Ras1 is a member of the small guanosine triphosphatases family, which plays a crucial role in regulating various cellular pathways, particularly those involving the NFκB signaling cascade. κB-Ras1 is primarily located in the cytoplasm, where κB-Ras1 interacts with IκB proteins, specifically IκBα and IκBβ, to modulate their degradation rates. The ability of κB-Ras1 to stabilize IκB proteins is significant because κB-Ras1 influences the activation of NFκB, a transcription factor that regulates genes involved in immune response, cell proliferation, and survival. By preventing the degradation of IκBβ, κB-Ras1 contributes to the maintenance of NFκB in an inactive state in the cytoplasm, thereby controlling NFκB translocation to the nucleus and subsequent gene expression. The unique structural features of κB-Ras1, including amino acid composition that resembles oncogenic Ras proteins, further underscore κB-Ras1′s importance in cellular signaling and potential implications in cancer biology. anti-κB-Ras1 antibody (C-7) is an essential tool for researchers investigating the intricate roles of Ras-like proteins in cellular processes.

The preferred κB-Ras1 antibody is κB-Ras1 Antibody (E-3): sc-271169.