Junctophilin-2 Antibody (B-6): sc-398125

Junctophilin-2 Antibody (B-6) is a mouse monoclonal IgG1 antibody that detects Junctophilin-2 (JPH2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). JPH2 plays a crucial role in forming junctional complexes between the plasma membrane and the endoplasmic reticulum or sarcoplasmic reticulum, which is essential for proper functioning of excitable cells, particularly in cardiac and skeletal muscle tissues. JPH2′s unique structure includes a cytoplasmic domain that anchors to the plasma membrane and a hydrophobic C-terminal segment that spans the ER/SR membrane, facilitating close apposition of these membranes. This structural arrangement is vital for calcium signaling regulation, as anti-JPH2 antibody (B-6) allows for efficient communication between the two organelles, thereby influencing muscle contraction and overall cellular excitability. Disruption of JPH2 function, as seen in mutant mice lacking the Jph2 gene, leads to severe consequences such as embryonic lethality and abnormal calcium transients in cardiac myocytes, underscoring JPH2′s importance in maintaining cellular homeostasis and function. JPH2 monoclonal antibody (B-6) serves as an invaluable tool for researchers studying the intricate mechanisms of muscle physiology and related disorders.

The preferred Junctophilin-2 antibody is Junctophilin-2 Antibody (H-3): sc-377086.