Junctophilin-2 Antibody (A-1): sc-398290

Junctophilin-2 Antibody (A-1) is a mouse monoclonal IgG2b antibody that detects Junctophilin-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Junctophilin-2 plays a crucial role in the formation of junctional complexes between the plasma membrane and the endoplasmic reticulum, which is essential for maintaining calcium signaling in excitable cells, particularly in cardiac and skeletal muscle. Junctophilin-2′s localization at these junctions is vital for the proper functioning of excitation-contraction coupling, a process that allows muscle cells to contract in response to electrical signals. Disruption of Junctophilin-2 function can lead to severe cardiac dysfunction, as evidenced by studies on mutant mice lacking the Jph2 gene, which exhibit embryonic lethality and abnormal calcium transients in cardiac myocytes. Anti-Junctophilin-2 antibody (A-1) is an invaluable tool for researchers investigating the molecular mechanisms underlying muscle physiology and related pathologies.

The preferred Junctophilin-2 antibody is Junctophilin-2 Antibody (H-3): sc-377086.