JMJD4 Antibody (D-10): sc-514881
- JMJD4 Antibody (D-10) is a mouse monoclonal IgG2b κ JMJD4 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 429-445 near the C-terminus of JMJD4 of human origin
- JMJD4 Antibody (D-10) is recommended for detection of JMJD4 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-JMJD4 Antibody (D-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for JMJD4 Antibody (D-10) for WB applications. These reagents are now offered in bundles with JMJD4 Antibody (D-10) (see ordering information below).
JMJD4 Antibody (D-10) is a mouse monoclonal IgG2b kappa light chain antibody that detects JMJD4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). JMJD4 (D-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. JMJD4, also known as Jumonji domain-containing protein 4, plays a pivotal role in regulating chromatin dynamics and gene transcription through its function as a histone demethylase. Specifically, JMJD4 removes methyl groups from lysine residues on histones, which is crucial for modulating chromatin structure and gene expression. This process maintains cellular identity and function by influencing transcriptional activity of genes vital for various biological processes, including development and cellular response to environmental signals. JMJD4′s ability to regulate gene expression through histone modification underscores its importance in epigenetic regulation and cellular differentiation, making JMJD4 a significant target for research in developmental biology and cancer studies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
JMJD4 Antibody (D-10) References:
- Histone demethylation by a family of JmjC domain-containing proteins. | Tsukada, Y., et al. 2006. Nature. 439: 811-6. PMID: 16362057
- The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. | Cloos, PA., et al. 2006. Nature. 442: 307-11. PMID: 16732293
- JmjC-domain-containing proteins and histone demethylation. | Klose, RJ., et al. 2006. Nat Rev Genet. 7: 715-27. PMID: 16983801
- JMJD6 is a histone arginine demethylase. | Chang, B., et al. 2007. Science. 318: 444-7. PMID: 17947579
- Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. | Hong, S., et al. 2007. Proc Natl Acad Sci U S A. 104: 18439-44. PMID: 18003914
- Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. | Pfau, R., et al. 2008. Proc Natl Acad Sci U S A. 105: 1907-12. PMID: 18250326
- Histone lysine methyltransferases and demethylases in Plasmodium falciparum. | Cui, L., et al. 2008. Int J Parasitol. 38: 1083-97. PMID: 18299133
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JMJD4 Antibody (D-10) | sc-514881 | 200 µg/ml | $322.00 | |||
JMJD4 Antibody (D-10): m-IgGκ BP-HRP Bundle | sc-524871 | 200 µg Ab, 40 µg BP | $361.00 | |||
JMJD4 Antibody (D-10): m-IgG2b BP-HRP Bundle | sc-549192 | 200 µg Ab; 10 µg BP | $361.00 | |||
JMJD4 Antibody (D-10) AC | sc-514881 AC | 500 µg/ml, 25% agarose | $424.00 | |||
JMJD4 Antibody (D-10) HRP | sc-514881 HRP | 200 µg/ml | $322.00 | |||
JMJD4 Antibody (D-10) FITC | sc-514881 FITC | 200 µg/ml | $336.00 | |||
JMJD4 Antibody (D-10) PE | sc-514881 PE | 200 µg/ml | $349.00 | |||
JMJD4 Antibody (D-10) Alexa Fluor® 488 | sc-514881 AF488 | 200 µg/ml | $364.00 | |||
JMJD4 Antibody (D-10) Alexa Fluor® 546 | sc-514881 AF546 | 200 µg/ml | $364.00 | |||
JMJD4 Antibody (D-10) Alexa Fluor® 594 | sc-514881 AF594 | 200 µg/ml | $364.00 | |||
JMJD4 Antibody (D-10) Alexa Fluor® 647 | sc-514881 AF647 | 200 µg/ml | $364.00 | |||
JMJD4 Antibody (D-10) Alexa Fluor® 680 | sc-514881 AF680 | 200 µg/ml | $364.00 | |||
JMJD4 Antibody (D-10) Alexa Fluor® 790 | sc-514881 AF790 | 200 µg/ml | $364.00 | |||
JMJD4 (D-10) Neutralizing Peptide | sc-514881 P | 100 µg/0.5 ml | $69.00 |