JMJD4 Activators
JMJD4 activators belong to a distinct chemical class known for their ability to modulate the activity of Jumonji domain-containing protein 4 (JMJD4), a member of the Jumonji C (JmjC) domain-containing protein family. The JmjC domain is a conserved motif found in proteins that possess histone demethylase activity, and JMJD4 itself plays a pivotal role in epigenetic regulation by catalyzing the removal of methyl groups from histone proteins. The chemical class of JMJD4 activators is characterized by its unique molecular structure, which facilitates interactions with specific binding sites on JMJD4, consequently leading to enhanced enzymatic activity. The activation of JMJD4 is crucial in cellular processes such as transcriptional regulation, as it participates in the dynamic control of chromatin structure through the demethylation of histones.
Structurally diverse, JMJD4 activators typically feature chemical moieties that enable them to engage in selective and potent interactions with the catalytic domain of JMJD4. This engagement induces conformational changes within the protein, ultimately promoting its enzymatic activity. By modulating JMJD4 function, these activators contribute to the intricate network of epigenetic modifications that govern gene expression. The elucidation of the specific mechanisms by which JMJD4 activators operate opens avenues for a deeper understanding of the intricate regulatory pathways involved in cellular processes. The chemical class of JMJD4 activators thus represents a promising area of research in the exploration of epigenetic modulation and its impact on fundamental biological processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
An inhibitor of DNA methyltransferase, 5-Azacytidine can indirectly enhance the activity of JMJD4, a histone demethylase. The inhibition of DNA methylation changes the chromatin structure, making it more accessible for JMJD4 to carry out its functions. | ||||||
Tranylcypromine | 13492-01-8 | sc-200572 sc-200572A | 1 g 5 g | $175.00 $599.00 | 5 | |
Tranylcypromine is a monoamine oxidase inhibitor that can also inhibit KDM1, a histone demethylase. This can enhance the activity of JMJD4 as it reduces competition for the same substrates. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase (HDAC) inhibitor. HDAC inhibition results in histone hyperacetylation, which may indirectly increase the activity of JMJD4, as the presence of acetylation can alter the recruitment of demethylases. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
EPZ004777 is a potent, selective DOT1L inhibitor. By inhibiting DOT1L, it indirectly enhances the activity of JMJD4 by reducing the competition for histone methylation sites. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 is a specific inhibitor of the histone methyltransferase G9a. By inhibiting G9a, BIX-01294 can enhance the function of JMJD4 indirectly by reducing the methylation of histone substrates, allowing JMJD4 to more effectively carry out its demethylation function. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $84.00 $301.00 $374.00 $779.00 | 25 | |
DMOG is a prolyl hydroxylase inhibitor that stabilizes the hypoxia-inducible factor (HIF). By stabilizing HIF, DMOG can indirectly increase the activity of JMJD4, as HIF can bind to the JMJD4 promoter and enhance its transcription. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a non-nucleoside inhibitor of DNA methyltransferases. By inhibiting DNA methyltransferases, RG108 can indirectly enhance the function of JMJD4 by reducing DNA methylation, thus altering the chromatin structure and making it more accessible for JMJD4 to carry out its functions. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is an NF-κB inhibitor. By inhibiting NF-κB, it can indirectly increase the activity of JMJD4 as NF-κB can bind to the JMJD4 promoter and repress its transcription. | ||||||