JIP-2 Antibody (C-10): sc-398926

JIP-2 Antibody (C-10) is a mouse monoclonal IgG2a antibody that detects JIP-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). JIP-2, a member of the JNK-interacting protein family, plays a crucial role in the regulation of c-Jun NH2-terminal kinases (JNKs) by acting as a scaffold that facilitates the interaction between JNKs and their substrates, thereby influencing various signaling pathways involved in stress responses and apoptosis. JIP-2 is predominantly located in the cytoplasm, where JIP-2 not only modulates JNK activity but also participates in the organization of signaling complexes that are essential for cellular responses to environmental stressors. Proper localization of JIP-2 ensures that JNK signaling is appropriately regulated, preventing aberrant activation that could lead to pathological conditions such as cancer or neurodegenerative diseases. JIP-2 also interacts with other proteins, including JNK1 and JNK2, which enhances JIP-2′s role in the JNK signaling cascade. Multiple splice variants of JIP-2 further underscore JIP-2′s functional diversity and importance in cellular signaling. Anti-JIP-2 antibody (C-10) is an invaluable tool for researchers studying the intricate mechanisms of JNK signaling and its implications in human health and disease.

The preferred JIP-2 antibody is JIP-2 Antibody (A-9): sc-377490.