JIP-2 Antibody (1E11): sc-53553

JIP-2 Antibody (1E11) is a mouse monoclonal IgG1 antibody that detects JIP-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). JIP-2, a member of the JNK-interacting protein family, plays a crucial role in regulating c-Jun NH2-terminal kinases (JNKs) by acting as a scaffold that facilitates interaction between JNKs and their substrates, influencing various signaling pathways involved in stress responses and apoptosis. JIP-2 is predominantly located in the cytoplasm, where JIP-2 not only modulates JNK activity but also participates in assembling signaling complexes essential for cellular responses to environmental stressors. This localization allows JIP-2 to effectively regulate JNK signaling in response to stimuli such as ultraviolet light and oxidative stress, ultimately impacting gene expression and cell survival. JIP-2 also exhibits multiple splice variants, contributing to functional diversity and regulatory mechanisms in different cellular contexts. Through interactions with other proteins in the JNK signaling pathway, JIP-2 maintains cellular homeostasis and stress response, making JIP-2 an important target for research in cancer and neurodegenerative diseases.

The preferred JIP-2 antibody is JIP-2 Antibody (A-9): sc-377490.