JAK2 Antibody (C-10): sc-390539
- JAK2 Antibody (C-10) is a mouse monoclonal IgG2b κ JAK2 antibody, cited in 53 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 752-780 of JAK2 of mouse origin
- JAK2 Antibody (C-10) is recommended for detection of JAK2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-JAK2 Antibody (C-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to biotin for WB, IHC(P) and ELISA
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of JAK2 (C-10): sc-390539.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for JAK2 Antibody (C-10) for WB applications. These reagents are now offered in bundles with JAK2 Antibody (C-10) (see ordering information below).
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JAK2 Antibody (C-10) is a mouse monoclonal IgG2b kappa light chain antibody specifically engineered to detect Janus kinase 2 (JAK2), also known as Tyrosine-protein kinase JAK2. JAK2 monoclonal antibody (C-10) targets an epitope within amino acids 752-780 of the mouse JAK2 protein, ensuring effective recognition of JAK2 across mouse, rat, and human species in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Janus kinase 2 is a vital member of the non-receptor Janus tyrosine kinase family, integral to the JAK/STAT signaling pathway that regulates essential cellular functions including proliferation, differentiation, and survival within the immune and hematopoietic systems. Upon activation by cytokines and interferons, JAK2 phosphorylates STAT transcription factors, which then dimerize and migrate to the nucleus to modulate gene expression. This signaling mechanism is crucial for maintaining immune homeostasis and orchestrating responses to pathogens. Dysregulation of JAK2 activity is associated with various inflammatory diseases and cancers, highlighting JAK2′s importance as a therapeutic target. Anti-JAK2 antibody (C-10) serves as an invaluable tool for researchers investigating the molecular pathways involved in immune regulation and disease progression, facilitating the development of targeted therapies aimed at modulating JAK2 activity to treat inflammatory and oncogenic conditions effectively.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
JAK2 Antibody (C-10) References:
- Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes. | Kotenko, SV. and Pestka, S. 2000. Oncogene. 19: 2557-65. PMID: 10851054
- Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids. | Bianchi, M., et al. 2000. Proc Natl Acad Sci U S A. 97: 9573-8. PMID: 10920190
- Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction. | Negoro, S., et al. 2000. Cardiovasc Res. 47: 797-805. PMID: 10974228
- Inhibition of IFN-gamma-induced janus kinase-1-STAT1 activation in macrophages by vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. | Delgado, M. and Ganea, D. 2000. J Immunol. 165: 3051-7. PMID: 10975815
- The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus. | Heim, MH. 1996. Eur J Clin Invest. 26: 1-12. PMID: 8682149
- Jaks, Stats and the immune system. | Decker, T. and Meinke, A. 1997. Immunobiology. 198: 99-111. PMID: 9442382
- Jaks and STATs: biological implications. | Leonard, WJ. and O'Shea, JJ. 1998. Annu Rev Immunol. 16: 293-322. PMID: 9597132
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAK2 Antibody (C-10) | sc-390539 | 200 µg/ml | $316.00 | |||
JAK2 Antibody (C-10): m-IgGκ BP-HRP Bundle | sc-523574 | 200 µg Ab, 40 µg BP | $354.00 | |||
JAK2 Antibody (C-10): m-IgG2b BP-HRP Bundle | sc-549127 | 200 µg Ab; 10 µg BP | $354.00 | |||
JAK2 Antibody (C-10) AC | sc-390539 AC | 500 µg/ml, 25% agarose | $416.00 | |||
JAK2 Antibody (C-10) HRP | sc-390539 HRP | 200 µg/ml | $316.00 | |||
JAK2 Antibody (C-10) FITC | sc-390539 FITC | 200 µg/ml | $330.00 | |||
JAK2 Antibody (C-10) PE | sc-390539 PE | 200 µg/ml | $343.00 | |||
JAK2 Antibody (C-10) Alexa Fluor® 488 | sc-390539 AF488 | 200 µg/ml | $357.00 | |||
JAK2 Antibody (C-10) Alexa Fluor® 546 | sc-390539 AF546 | 200 µg/ml | $357.00 | |||
JAK2 Antibody (C-10) Alexa Fluor® 594 | sc-390539 AF594 | 200 µg/ml | $357.00 | |||
JAK2 Antibody (C-10) Alexa Fluor® 647 | sc-390539 AF647 | 200 µg/ml | $357.00 | |||
JAK2 Antibody (C-10) Alexa Fluor® 680 | sc-390539 AF680 | 200 µg/ml | $357.00 | |||
JAK2 Antibody (C-10) Alexa Fluor® 790 | sc-390539 AF790 | 200 µg/ml | $357.00 | |||
JAK2 Antibody (C-10) B | sc-390539 B | 200 µg/ml | $320.00 | |||
JAK2 (C-10) Neutralizing Peptide | sc-390539 P | 100 µg/0.5 ml | $68.00 |