ITPase Antibody (A-4): sc-514409
- ITPase Antibody (A-4) is a mouse monoclonal IgG1 κ ITPase antibody provided at 200 µg/ml
- raised against amino acids 1-194 representing full length ITPase of human origin
- ITPase Antibody (A-4) is recommended for detection of ITPase of human origin by WB, IP, IF and ELISA
- Anti-ITPase Antibody (A-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of ITPase (A-4): sc-514409.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ITPase Antibody (A-4) for WB applications. These reagents are now offered in bundles with ITPase Antibody (A-4) (see ordering information below).
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ITPase Antibody (A-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects ITPase protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ITPase Antibody (A-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ITPase, also known as inosine triphosphate pyrophosphatase or putative oncogene protein hlc14-06-p, is a 194 amino acid protein that plays a crucial role in nucleotide metabolism by catalyzing the conversion of inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) into inosine monophosphate (IMP) and diphosphate. This enzymatic activity is vital for maintaining the balance of nucleotide pools within the cell, as an excess of ITP can lead to cellular dysfunction and has been implicated in various pathological conditions. ITPase is predominantly localized in the cytoplasm and is highly expressed in tissues such as the heart, liver, sex glands, thyroid, and adrenal glands. Deficiencies in ITPase can result in an accumulation of ITP in erythrocytes, leukocytes, and fibroblasts, which is thought to be inherited and can lead to significant metabolic disturbances.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ITPase Antibody (A-4) References:
- Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation. | Breen, DP., et al. 2005. Liver Transpl. 11: 826-833. PMID: 15973722
- Pharmacogenetic significance of inosine triphosphatase. | Bierau, J., et al. 2007. Pharmacogenomics. 8: 1221-8. PMID: 17924837
- Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli. | Savchenko, A., et al. 2007. J Mol Biol. 374: 1091-103. PMID: 17976651
- Characterization of the inosine triphosphatase (ITPA) gene: haplotype structure, haplotype-phenotype correlation and promoter function. | von Ahsen, N., et al. 2008. Ther Drug Monit. 30: 16-22. PMID: 18223458
- ITPase activity in dry blood spots is comparable with that in fresh erythrocytes. | Tomkova, J., et al. 2008. Nucleosides Nucleotides Nucleic Acids. 27: 656-60. PMID: 18600522
- Individual variation of nucleoside triphosphate pyrophosphohydrolase activity in human erythrocytes, granulocytes, lymphocytes, and platelets. | Verhoef, VL., et al. 1980. Biochem Genet. 18: 235-45. PMID: 6108768
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ITPase Antibody (A-4) | sc-514409 | 200 µg/ml | $316.00 | |||
ITPase Antibody (A-4): m-IgG Fc BP-HRP Bundle | sc-531114 | 200 µg Ab; 10 µg BP | $354.00 | |||
ITPase Antibody (A-4): m-IgGκ BP-HRP Bundle | sc-524713 | 200 µg Ab, 40 µg BP | $354.00 | |||
ITPase Antibody (A-4): m-IgG1 BP-HRP Bundle | sc-544402 | 200 µg Ab; 20 µg BP | $354.00 | |||
ITPase Antibody (A-4) AC | sc-514409 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ITPase Antibody (A-4) HRP | sc-514409 HRP | 200 µg/ml | $316.00 | |||
ITPase Antibody (A-4) FITC | sc-514409 FITC | 200 µg/ml | $330.00 | |||
ITPase Antibody (A-4) PE | sc-514409 PE | 200 µg/ml | $343.00 | |||
ITPase Antibody (A-4) Alexa Fluor® 488 | sc-514409 AF488 | 200 µg/ml | $357.00 | |||
ITPase Antibody (A-4) Alexa Fluor® 546 | sc-514409 AF546 | 200 µg/ml | $357.00 | |||
ITPase Antibody (A-4) Alexa Fluor® 594 | sc-514409 AF594 | 200 µg/ml | $357.00 | |||
ITPase Antibody (A-4) Alexa Fluor® 647 | sc-514409 AF647 | 200 µg/ml | $357.00 | |||
ITPase Antibody (A-4) Alexa Fluor® 680 | sc-514409 AF680 | 200 µg/ml | $357.00 | |||
ITPase Antibody (A-4) Alexa Fluor® 790 | sc-514409 AF790 | 200 µg/ml | $357.00 |