IRX3 Antibody (F-8): sc-166657
- IRX3 Antibody (F-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 361-507 mapping at the C-terminus of IRX3 of mouse origin
- recommended for detection of IRX3 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-166657 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for IRX3 Antibody (F-8) for WB applications. This reagent is now offered in a bundle with IRX3 Antibody (F-8) (see ordering information below).
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IRX3 Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects IRX3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IRX3 is a member of the Iroquois homeobox gene family, which plays a crucial role in regulating embryonic development, particularly in the formation of the central nervous system and the heart. IRX3 (F-8) antibody targets proteins primarily located in the ventricular trabeculated myocardium during heart development, where IRX3 is essential for proper cardiac morphogenesis. IRX3 expression in this specific region underscores IRX3′s importance in the development of the heart′s structure and function, as IRX3 helps establish the intricate architecture necessary for effective cardiac performance. Disruptions in IRX3 expression can lead to developmental anomalies, highlighting IRX3′s critical role in ensuring normal heart formation. Through interactions with other transcription factors and signaling pathways, IRX3 coordinates complex processes involved in cardiac development, making anti-IRX3 antibody (F-8) an invaluable tool for researchers studying heart development and related pathologies.
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IRX3 Antibody (F-8) References:
- Obesity-associated variants within FTO form long-range functional connections with IRX3. | Smemo, S., et al. 2014. Nature. 507: 371-5. PMID: 24646999
- IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk. | Zou, Y., et al. 2017. EBioMedicine. 24: 64-75. PMID: 28988979
- The homeobox factor Irx3 maintains adipogenic identity. | Bjune, JI., et al. 2020. Metabolism. 103: 154014. PMID: 31751577
- IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis. | Tan, Z., et al. 2020. J Bone Miner Res. 35: 2444-2457. PMID: 32662900
- IRX3 Overexpression Enhances Ucp1 Expression In Vivo. | Zhang, Z., et al. 2021. Front Endocrinol (Lausanne). 12: 634191. PMID: 33776928
- Irx3 and Irx5 in Ins2-Cre+ cells regulate hypothalamic postnatal neurogenesis and leptin response. | Son, JE., et al. 2021. Nat Metab. 3: 701-713. PMID: 33859429
- Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation. | Yao, J., et al. 2021. Nat Immunol. 22: 1268-1279. PMID: 34556885
- Irx3 and Irx5 - Novel Regulatory Factors of Postnatal Hypothalamic Neurogenesis. | Dou, Z., et al. 2021. Front Neurosci. 15: 763856. PMID: 34795556
- IRX3 promotes adipose tissue browning and inhibits fibrosis in obesity-resistant mice. | Yan, XY., et al. 2024. Int J Biochem Cell Biol. 175: 106638. PMID: 39173825
- Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia. | Rahman, S., et al. 2024. Blood. 144: 2319-2326. PMID: 39316719
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IRX3 Antibody (F-8) | sc-166657 | 200 µg/ml | $316.00 | |||
IRX3 Antibody (F-8): m-IgG Fc BP-HRP Bundle | sc-540137 | 200 µg Ab; 10 µg BP | $354.00 | |||
IRX3 Antibody (F-8) X | sc-166657 X | 200 µg/0.1 ml | $316.00 |