IRP-2 Antibody (4G11): sc-33680
- IRP-2 Antibody (4G11) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 138-200 of IRP-2 (iron regulatory protein-2) of human origin
- Anti-IRP-2 Antibody (4G11) is recommended for detection of IRP-2 of mouse, rat and human origin by WB, IP and IF
- Anti-IRP-2 Antibody (4G11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for IRP-2 Antibody (4G11) for WB applications. These reagents are now offered in bundles with IRP-2 Antibody (4G11) (see ordering information below).
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IRP-2 Antibody (4G11) is a mouse monoclonal IgG1 kappa light chain antibody that detects IRP-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). IRP-2 Antibody (4G11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IRP-2 plays a crucial role in iron metabolism, which is vital for maintaining cellular homeostasis. Located primarily in the cytoplasm, IRP-2 functions as a key regulator of iron uptake and storage by binding to iron-responsive elements (IREs) in mRNA, thereby influencing the translation of proteins involved in iron transport and storage. This regulatory mechanism ensures that cells can adapt to varying iron levels and respond to oxidative stress, which can be detrimental if iron levels are not properly managed. By modulating the expression of proteins such as transferrin receptor and ferritin, IRP-2 helps maintain a delicate balance of iron within the cell, preventing both deficiency and toxicity. The ability of IRP-2 to respond to changes in iron concentration and other signaling factors underscores its importance in cellular health and disease, making anti-IRP-2 antibody (4G11) a valuable tool for researchers studying iron metabolism and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IRP-2 Antibody (4G11) References:
- IRP2 regulates breast tumor growth. | Wang, W., et al. 2014. Cancer Res. 74: 497-507. PMID: 24285726
- Irp2 Knockout Causes Osteoporosis by Inhibition of Bone Remodeling. | Zhou, Y., et al. 2019. Calcif Tissue Int. 104: 70-78. PMID: 30191282
- Mdm2 is a target and mediator of IRP2 in cell growth control. | Zhang, J., et al. 2020. FASEB J. 34: 2301-2311. PMID: 31907996
- FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster. | Wang, H., et al. 2020. Mol Cell. 78: 31-41.e5. PMID: 32126207
- Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5. | Terzi, EM., et al. 2021. Sci Adv. 7: PMID: 34039609
- β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer. | Wu, Y., et al. 2023. J Transl Med. 21: 50. PMID: 36703130
- Stimulation of Hepatic Ferritinophagy Mitigates Irp2 Depletion-Induced Anemia. | Liu, Y., et al. 2023. Antioxidants (Basel). 12: PMID: 36978814
- A regulatory module comprising G3BP1-FBXL5-IRP2 axis determines sodium arsenite-induced ferroptosis. | Liu, Q., et al. 2024. J Hazard Mater. 465: 133038. PMID: 38118197
- The involvement of IRP2-induced ferroptosis through the p53-SLC7A11-ALOX12 pathway in Parkinson's disease. | Yao, Z., et al. 2024. Free Radic Biol Med. 222: 386-396. PMID: 38936518
- Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancer. | Hwang, J., et al. 2024. Cell Commun Signal. 22: 412. PMID: 39180081
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IRP-2 Antibody (4G11) | sc-33680 | 200 µg/ml | $322.00 | |||
IRP-2 Antibody (4G11): m-IgG Fc BP-HRP Bundle | sc-526705 | 200 µg Ab; 10 µg BP | $361.00 | |||
IRP-2 Antibody (4G11): m-IgG1 BP-HRP Bundle | sc-532078 | 200 µg Ab; 20 µg BP | $361.00 | |||
IRP-2 Antibody (4G11) AC | sc-33680 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IRP-2 Antibody (4G11) HRP | sc-33680 HRP | 200 µg/ml | $322.00 | |||
IRP-2 Antibody (4G11) FITC | sc-33680 FITC | 200 µg/ml | $336.00 | |||
IRP-2 Antibody (4G11) PE | sc-33680 PE | 200 µg/ml | $349.00 | |||
IRP-2 Antibody (4G11) Alexa Fluor® 488 | sc-33680 AF488 | 200 µg/ml | $364.00 | |||
IRP-2 Antibody (4G11) Alexa Fluor® 546 | sc-33680 AF546 | 200 µg/ml | $364.00 | |||
IRP-2 Antibody (4G11) Alexa Fluor® 594 | sc-33680 AF594 | 200 µg/ml | $364.00 | |||
IRP-2 Antibody (4G11) Alexa Fluor® 647 | sc-33680 AF647 | 200 µg/ml | $364.00 | |||
IRP-2 Antibody (4G11) Alexa Fluor® 680 | sc-33680 AF680 | 200 µg/ml | $364.00 | |||
IRP-2 Antibody (4G11) Alexa Fluor® 790 | sc-33680 AF790 | 200 µg/ml | $364.00 |