IRP-2 Antibody (14F7): sc-33681

IRP-2 Antibody (14F7) is a mouse monoclonal IgG1 antibody that detects IRP-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). IRP-2, or iron regulatory protein-2, plays a crucial role in iron homeostasis by regulating the expression of genes involved in iron metabolism. IRP-2 is primarily located in the cytoplasm and is essential for maintaining cellular iron levels, as IRP-2 modulates the translation of ferritin and transferrin receptor mRNAs in response to iron availability. The binding of IRP-2 to iron-responsive elements in these mRNAs allows for either translation inhibition or mRNA stabilization, thereby ensuring that cells can adapt to varying iron conditions. Dysregulation of IRP-2 can lead to iron overload or deficiency, which is associated with various diseases, including neurodegenerative disorders and anemia. IRP-2 (14F7) antibody is a valuable tool for researchers studying iron metabolism and its implications in health and disease, providing insights into the intricate balance of iron regulation within human cells.

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IRP-2 Antibody (14F7) References:

1. The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.  |  Moroishi, T., et al. 2011. Cell Metab. 14: 339-51. PMID: 21907140
2. Occurrence and analysis of irp2 virulence gene in isolates of Klebsiella pneumoniae and Enterobacter spp. from microbiota and hospital and community-acquired infections.  |  Souza Lopes, AC., et al. 2016. Microb Pathog. 96: 15-9. PMID: 27133266
3. Influence of sodium nitroprusside on expressions of FBXL5 and IRP2 in SH-SY5Y cells.  |  Wei, J., et al. 2017. Sheng Li Xue Bao. 69: 261-266. PMID: 28638917
4. Iron overload induced by IRP2 gene knockout aggravates symptoms of Parkinson's disease.  |  Ci, YZ., et al. 2020. Neurochem Int. 134: 104657. PMID: 31904393
5. Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.  |  Santos, MCFD., et al. 2020. Nat Commun. 11: 296. PMID: 31941883
6. Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms.  |  Nadimpalli, HP., et al. 2024. Genome Biol. 25: 128. PMID: 38773499
7. FGFR1 governs iron homeostasis via regulating intracellular protein degradation pathways of IRP2 in prostate cancer cells.  |  Lin, H., et al. 2024. Commun Biol. 7: 1011. PMID: 39154074
8. A bulge uridine in the HIF2α IRE allows IRP1 but not IRP2 to selectively regulate HIF2α expression and ensuing EPO levels.  |  Zhang, DL., et al. 2025. Blood. 145: 533-542. PMID: 39316647
9. The deubiquitinase OTUD3 stabilizes IRP2 expression to reduce hippocampal neuron ferroptosis via the p53/PTGS2 pathway to ameliorate cerebral ischemia-reperfusion injury.  |  Hou, D., et al. 2024. Eur J Med Res. 29: 498. PMID: 39415292
10. Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels.  |  Guo, B., et al. 1995. J Biol Chem. 270: 16529-35. PMID: 7622457

The preferred IRP-2 antibody is IRP-2 Antibody (7H6): sc-33682.