IRF-1 Antibody (F-8): sc-514934
- IRF-1 Antibody (F-8) is a mouse monoclonal IgG1, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 304-328 at the C-terminus of IRF-1 of mouse origin
- recommended for detection of IRF-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-514934 X, 200 µg/0.1 ml)
- See IRF-1 (E-4): sc-514544 for IRF-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for IRF-1 Antibody (F-8) for WB applications. These reagents are now offered in bundles with IRF-1 Antibody (F-8) (see ordering information below).
IRF-1 Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects interferon regulatory factor-1 (IRF-1) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IRF-1 plays a crucial role in the immune response by acting as a transcriptional activator for type I interferon genes, which are essential for the antiviral response and regulation of immune cell functions. IRF-1 is primarily located in the nucleus, where IRF-1 binds to specific DNA sequences in the promoters of interferon-α and interferon-β genes, facilitating their transcription. This nuclear localization allows IRF-1 to exert regulatory effects on gene expression in response to viral infections and other immune stimuli. The balance between IRF-1 and IRF-2 repressor is critical for maintaining cellular homeostasis; dysregulation of this balance can lead to abnormal cell growth and transformation, highlighting IRF-1′s importance in both immune regulation and potential oncogenesis. Anti-IRF-1 antibody (F-8) is an invaluable tool for researchers studying the intricate mechanisms of immune regulation and the role of interferon signaling in various diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IRF-1 Antibody (F-8) | sc-514934 | 200 µg/ml | $316.00 | |||
IRF-1 Antibody (F-8): m-IgG Fc BP-HRP Bundle | sc-541013 | 200 µg Ab; 10 µg BP | $354.00 | |||
IRF-1 Antibody (F-8): m-IgG1 BP-HRP Bundle | sc-542529 | 200 µg Ab; 20 µg BP | $354.00 | |||
IRF-1 (F-8) Neutralizing Peptide | sc-514934 P | 100 µg/0.5 ml | $68.00 | |||
IRF-1 Antibody (F-8) X | sc-514934 X | 200 µg/0.1 ml | $316.00 |