IRF-1 Antibody (B-1): sc-137061

IRF-1 Antibody (B-1) is a mouse monoclonal IgG1 antibody that detects interferon regulatory factor-1 (IRF-1) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IRF-1 plays a crucial role in the immune response by acting as a transcriptional activator for type I interferon genes, which are essential for the antiviral response and regulation of immune cell activity. IRF-1 is primarily located in the nucleus, where IRF-1 binds to specific DNA sequences in the promoters of interferon-α and interferon-β genes, facilitating their transcription. This nuclear localization enables IRF-1 to exert regulatory effects on gene expression in response to viral infections and other immune stimuli. Furthermore, IRF-1′s ability to interact with other members of the interferon regulatory factor family, such as IRF-2, underscores IRF-1′s importance in maintaining a balanced immune response, as these proteins can function antagonistically to modulate cell growth and immune signaling pathways. Anti-IRF-1 antibody (B-1) is an invaluable tool for researchers studying the intricate mechanisms of immune regulation and the role of interferon signaling in various diseases.

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IRF-1 Antibody (B-1) References:

1. IRF-1-binding site in the first intron mediates interferon-γ-induced optineurin promoter activation.  |  Sudhakar, C., et al. 2013. Biochem Biophys Res Commun. 437: 179-84. PMID: 23811275
2. IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Rα production.  |  Yokota, S., et al. 2015. J Immunol. 194: 6045-56. PMID: 25964490
3. IRF-1 SNPs influence the risk for childhood allergic asthma: A critical role for pro-inflammatory immune regulation.  |  Landgraf-Rauf, K., et al. 2018. Pediatr Allergy Immunol. 29: 34-41. PMID: 29047170
4. Depleting interferon regulatory factor-1(IRF-1) with CRISPR/Cas9 attenuates inducible oxidative metabolism without affecting RA-induced differentiation in HL-60 human AML cells.  |  Zhu, K., et al. 2020. FASEB Bioadv. 2: 354-364. PMID: 32617521
5. IRF-1 expressed in the inner cell mass of the porcine early blastocyst enhances the pluripotency of induced pluripotent stem cells.  |  Shi, B., et al. 2020. Stem Cell Res Ther. 11: 505. PMID: 33246502
6. IRF-1 mediated long non-coding RNA PVT1-214 promotes oxaliplatin resistance of colorectal cancer via miR-128 inhibition.  |  Tong, D., et al. 2020. J BUON. 25: 2205-2214. PMID: 33277837
7. IRF-1 contributes to the pathological phenotype of VSMCs during atherogenesis by increasing CCL19 transcription.  |  Shen, Y., et al. 2020. Aging (Albany NY). 13: 933-943. PMID: 33424012
8. Interferon regulatory factor 1 (IRF-1) downregulates Checkpoint kinase 1 (CHK1) through miR-195 to upregulate apoptosis and PD-L1 expression in Hepatocellular carcinoma (HCC) cells.  |  Yan, Y., et al. 2021. Br J Cancer. 125: 101-111. PMID: 33772151
9. Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection.  |  Schmalzl, A., et al. 2022. Nat Commun. 13: 5730. PMID: 36175404
10. IRF-1 Regulates Mitochondrial Respiration and Intrinsic Apoptosis Under Metabolic Stress through ATP Synthase Ancillary Factor TMEM70.  |  Sun, C., et al. 2024. Inflammation.. PMID: 39641858

The preferred IRF-1 antibody is IRF-1 Antibody (H-8): sc-74530.