IRAK-1 Antibody (B-5): sc-55530
- IRAK-1 Antibody (B-5) is a mouse monoclonal IgG2b κ, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 440-712 mapping at the C-terminus of IRAK-1 of human origin
- recommended for detection of IRAK-1 of human origin by WB, IP, IF and ELISA
- See IRAK-1 (F-4): sc-5288 for IRAK-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IRAK-1 Antibody (B-5) for WB applications. These reagents are now offered in bundles with IRAK-1 Antibody (B-5) (see ordering information below).
IRAK-1 Antibody (B-5) is a mouse monoclonal IgG2b antibody that detects IRAK-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IRAK-1, or IL-1 receptor-associated kinase 1, plays a crucial role in the signaling pathways activated by interleukin-1 (IL-1), particularly in the activation of the NF-kB pathway, which is essential for regulating immune responses and inflammation. Located primarily in the cytoplasm, IRAK-1 is recruited to the IL-1 receptor complex upon ligand binding, where IRAK-1 undergoes phosphorylation and activation. This process is vital as IRAK-1 leads to the downstream activation of various transcription factors, including NF-kB, which in turn regulates the expression of numerous pro-inflammatory cytokines. The proper functioning of IRAK-1 is critical for maintaining immune homeostasis, and dysregulation of IRAK-1 activity has been implicated in various inflammatory diseases and conditions, making IRAK-1 a significant target for therapeutic intervention. Anti-IRAK-1 antibody (B-5) is an invaluable tool for researchers studying the intricate mechanisms of immune signaling and the pathophysiology of related diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IRAK-1 Antibody (B-5) | sc-55530 | 200 µg/ml | $322.00 | |||
IRAK-1 Antibody (B-5): m-IgG Fc BP-HRP Bundle | sc-537064 | 200 µg Ab; 10 µg BP | $361.00 | |||
IRAK-1 Antibody (B-5): m-IgGκ BP-HRP Bundle | sc-534250 | 200 µg Ab; 40 µg BP | $361.00 |