IQGAP2 Antibody (C-3): sc-55525

IQGAP2 Antibody (C-3) is a mouse monoclonal IgG1 antibody that detects IQGAP2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IQGAP2 is a crucial regulator of cell signaling and cytoskeletal dynamics, playing a significant role in the modulation of cadherin-mediated cell-cell adhesion. IQGAP2 is primarily located in the cytoplasm and at the cell membrane, where IQGAP2 interacts with small GTPases like Cdc42 and Rac1, as well as F-Actin and calmodulin. IQGAP2 localization is vital for function, as IQGAP2 facilitates the assembly of signaling complexes that are essential for maintaining cellular architecture and promoting cellular responses to external stimuli. By binding to the active GTP-bound forms of Cdc42 and Rac1, IQGAP2 inhibits their intrinsic GTPase activities, thereby sustaining their active states and influencing various cellular processes, including migration, proliferation, and differentiation. Anti-IQGAP2 antibody (C-3) is an invaluable tool for researchers studying the intricate mechanisms of cell signaling and adhesion, providing insights into IQGAP2 roles in health and disease.

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IQGAP2 Antibody (C-3) References:

1. IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells.  |  Jin, SH., et al. 2008. Int J Cancer. 122: 1040-6. PMID: 17957782
2. Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake.  |  Chiariello, CS., et al. 2012. Regul Pept. 173: 36-46. PMID: 21968151
3. IQGAP2, A candidate tumour suppressor of prostate tumorigenesis.  |  Xie, Y., et al. 2012. Biochim Biophys Acta. 1822: 875-84. PMID: 22406297
4. IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice.  |  Ghaleb, AM., et al. 2015. PLoS One. 10: e0129314. PMID: 26047140
5. Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling.  |  Deng, Z., et al. 2016. Int J Oncol. 48: 153-60. PMID: 26549344
6. IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-κB pathway.  |  Brisac, C., et al. 2016. J Hepatol. 65: 972-979. PMID: 27401546
7. Downregulation of IQGAP2 Correlates with Prostate Cancer Recurrence and Metastasis.  |  Xie, Y., et al. 2019. Transl Oncol. 12: 236-244. PMID: 30428404
8. IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity.  |  Xu, L., et al. 2020. Int J Mol Sci. 21: PMID: 32183047
9. Multi-omics data integration reveals the molecular network of dysregulation IQGAP2-mTOR promotes cell proliferation.  |  Chen, T., et al. 2023. Hum Cell. 36: 1429-1440. PMID: 37154877
10. Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling.  |  Sen, A., et al. 2023. J Biol Chem. 299: 105322. PMID: 37805137

The preferred IQGAP2 antibody is IQGAP2 Antibody (A-4): sc-17835.