IQGAP2 Activators

Ras GTPase-activating-like protein IQGAP2 activators encompass a range of compounds that can indirectly modulate the activity of IQGAP2 by influencing the signaling pathways and cellular processes in which IQGAP2 participates. The compounds listed, while not directly binding to or activating IQGAP2, could have an impact on the cellular milieu that regulates the function of IQGAP2. For example, forskolin by elevating cAMP levels, and PMA by activating PKC, can trigger a cascade of events leading to changes in actin dynamics, where IQGAP2 plays a crucial role.

Furthermore, the stability and polymerization of actin filaments, which are central to the function of IQGAP2, can be influenced by compounds like jasplakinolide and latrunculin B. Inhibitors of kinases and phosphatases that are involved in the signaling pathways affecting the cytoskeleton, such as Y-27632 and calyculin A, may also serve as indirect activators of IQGAP2 by altering its interaction with actin and other binding partners. Additionally, small molecule inhibitors of GTPases, such as ML141 and NSC23766, could lead to compensatory mechanisms that enhance the scaffolding function of IQGAP2. Inhibitors of broader signaling pathways, like LY294002, PD98059, and SB203580, might alter kinase activities that indirectly influence the role of IQGAP2 in cell adhesion and migration.