Integrin β8/ITGB8 Antibody (E-6): sc-514150

Integrin β8 Antibody (E-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects Integrin beta 8 (ITGB8) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Integrin β8 (E-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ITGB8 plays a crucial role in cell adhesion and signaling, functioning as a receptor that mediates interactions between cells and the extracellular matrix. ITGB8 is primarily located on the cell surface, where ITGB8 forms heterodimers with alpha subunits, contributing to the formation of more than 20 different integrin receptors. This localization allows ITGB8 to interact with ligands such as fibronectin and collagen, facilitating cellular responses essential for processes like migration, differentiation, and tissue repair. The ability of ITGB8 to bind to soluble ligands and counterreceptors on adjacent cells underscores ITGB8′s importance in cell aggregation and communication, making ITGB8 a key player in various physiological and pathological processes. Anti-Integrin β8 antibody (E-6) is an invaluable tool for researchers studying the intricate roles of integrins in cellular dynamics and their implications in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Integrin β8/ITGB8 Antibody (E-6) References:

1. Adhesion and migration of avian neural crest cells on fibronectin require the cooperating activities of multiple integrins of the (beta)1 and (beta)3 families.  |  Testaz, S., et al. 1999. J Cell Sci. 112 (Pt 24): 4715-28. PMID: 10574719
2. Determination of N- and C-terminal borders of the transmembrane domain of integrin subunits.  |  Stefansson, A., et al. 2004. J Biol Chem. 279: 21200-5. PMID: 15016834
3. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
4. Cloning and expression of a divergent integrin subunit beta 8.  |  Moyle, M., et al. 1991. J Biol Chem. 266: 19650-8. PMID: 1918072
5. The changing integrin expression and a role for integrin β8 in the chondrogenic differentiation of mesenchymal stem cells.  |  LaPointe, VL., et al. 2013. PLoS One. 8: e82035. PMID: 24312400
6. Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease.  |  Cao, Y., et al. 2024. Transl Res. 265: 36-50. PMID: 37931653
7. Integrin β8 Facilitates Macrophage Infiltration and Polarization by Regulating CCL5 to Promote LUAD Progression.  |  Song, L., et al. 2025. Adv Sci (Weinh). 12: e2406865. PMID: 39535362
8. Beta 8 integrins mediate interactions of chick sensory neurons with laminin-1, collagen IV, and fibronectin.  |  Venstrom, K. and Reichardt, L. 1995. Mol Biol Cell. 6: 419-31. PMID: 7542940
9. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
10. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
11. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
12. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin β8/ITGB8 Antibody (E-6) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin β8/ITGB8 Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin β8/ITGB8 Antibody (E-6) Specifications

Alternate Product Name: Integrin β8

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 64-87

Epitope Target: Integrin β8

Epitope Species: human

Product Reactivity/Detection: Integrin β8

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for Integrin β8/ITGB8 Antibody (E-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin