Integrin αX/ITGAX/CD11c Antibody (N418): sc-23951

Integrin αX Antibody (N418) is a hamster monoclonal IgG antibody that detects Integrin αX in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. Integrin αX is a type 1 transmembrane protein that plays a crucial role in the immune system by forming a leukocyte-specific integrin when combined with the β2 chain, known as the inactivated-C3b receptor 4 (CR4). This integrin is essential for mediating the adherence of neutrophils and monocytes to activated endothelial cells, as well as facilitating the phagocytosis of complement-coated particles, which is vital for an effective immune response. Abnormal expression of Integrin αX is notably associated with hairy cell leukemia, highlighting its significance in cancer biology and the activation of proto-oncogenes such as Ras and JunD. Furthermore, transcription of Integrin αX is influenced by various proteins and DNA elements, including Sp1, AP-1 family members, C/EBP, Oct-2, and PU.1, which underscores the complexity of its regulation. Integrin αX is predominantly found on monocyte-derived dendritic cells, macrophages, and natural killer cells, and upon activation, dendritic cells, particularly Langerhans cells located in the skin and mucosal tissues, migrate to lymphoid organs to interact with T and B cells, thereby initiating and shaping the adaptive immune response. Anti-Integrin αX antibody (N418) is an invaluable tool for researchers studying immune cell interactions and the underlying mechanisms of immune regulation.

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Integrin αX/ITGAX/CD11c Antibody (N418) References:

1. Regulated expression and function of CD11c/CD18 integrin on human B lymphocytes. Relation between attachment to fibrinogen and triggering of proliferation through CD11c/CD18.  |  Postigo, AA., et al. 1991. J Exp Med. 174: 1313-22. PMID: 1683891
2. Bone Marrow CD11c+ Cell-Derived Amphiregulin Promotes Pulmonary Fibrosis.  |  Ding, L., et al. 2016. J Immunol. 197: 303-12. PMID: 27206766
3. Clinical and histological significance of urinary CD11c+ macrophages in lupus nephritis.  |  Kim, J., et al. 2020. Arthritis Res Ther. 22: 173. PMID: 32680578
4. CD11c participates in triggering acute graft-versus-host disease during bone marrow transplantation.  |  Wang, Q., et al. 2021. Immunology. 164: 148-160. PMID: 33934334
5. Topical antibiotics reduce CD11c+ cell numbers in the healthy murine cornea and modulate their response to contact lens wear.  |  Datta, A., et al. 2022. Sci Rep. 12: 10655. PMID: 35739166
6. Fatal COVID-19 is Associated with Reduced HLA-DR, CD123 or CD11c Expression on Circulating Dendritic Cells.  |  Hasan, A., et al. 2022. J Inflamm Res. 15: 5665-5675. PMID: 36238761
7. Loss of Lkb1 in CD11c+ myeloid cells protects mice from diet-induced obesity while enhancing glucose intolerance and IL-17/IFN-γ imbalance.  |  Sun, Y., et al. 2023. Cell Mol Life Sci. 80: 63. PMID: 36781473
8. Saponin-based adjuvants enhance antigen cross-presentation in human CD11c+ CD1c+ CD5- CD163+ conventional type 2 dendritic cells.  |  Ho, NI., et al. 2023. J Immunother Cancer. 11: PMID: 37612044
9. Deletion of Pak1 in CD11c-Positive Cells Confers Resistance to Mouse Skin Carcinogenesis.  |  Okumura, K., et al. 2024. J Invest Dermatol. 144: 1890-1893.e5. PMID: 38325578
10. Impact of aquaporin-4 and CD11c + microglia in the development of ependymal cells in the aqueduct: inferences to hydrocephalus.  |  Mayo, F., et al. 2024. Fluids Barriers CNS. 21: 53. PMID: 38956598

The preferred Integrin αX/ITGAX/CD11c antibody is Integrin αX/ITGAX/CD11c Antibody (B-6): sc-46676.